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Publication Name World Journal of Hepatology
Manuscript ID 124436
Country Slovakia
Received
2026-06-15 02:11
Peer-Review Started
2026-06-15 02:11
First Decision by Editorial Office Director
Return for Revision
2026-07-03 09:22
Revised
2026-07-13 12:10
Publication Fee Transferred
Second Decision by Editor
2026-07-24 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-07-27 07:48
Articles in Press
2026-07-27 07:48
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-11 00:45
Publish the Manuscript Online
2026-08-18 03:51
ISSN 1948-5182 (online)
Open Access Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Small dense low-density lipoprotein in primary biliary cholangitis: Independent association with metabolic syndrome
Manuscript Source Invited Manuscript
All Author List Tomas Koky, Sylvia Drazilova, Martin Janicko, Martin Harhovsky, Beata Hubkova, Ivana Tothova, Miroslava Rabajdova, Maria Marekova and Peter Jarcuska
ORCID
Author(s) ORCID Number
Tomas Koky http://orcid.org/0000-0003-1932-055X
Sylvia Drazilova http://orcid.org/0000-0003-2448-6757
Martin Janicko http://orcid.org/0000-0002-3329-3968
Miroslava Rabajdova http://orcid.org/0000-0001-9562-5756
Peter Jarcuska http://orcid.org/0000-0001-6169-9984
Funding Agency and Grant Number
Corresponding Author Sylvia Drazilova, Associate Professor, MD, PhD, 2nd Department of Internal Medicine, PJ Safarik University, Faculty of Medicine and L Pasteur University Hospital, Trieda SNP 1, Kosice 04011, Slovakia. sylvia.drazilova@upjs.sk
Key Words Primary biliary cholangitis; Small dense low-density lipoprotein; Metabolic dysfunction; Lipoprotein subfractions; Atherogenic dyslipidemia
Core Tip Hypercholesterolemia in primary biliary cholangitis (PBC) is largely driven by cholestasis and lipoprotein X, making conventional lipid parameters difficult to interpret. In this study, small dense low-density lipoprotein (LDL) was independently associated with metabolic syndrome but not with liver fibrosis, cholestatic activity, metabolic dysfunction-associated steatotic liver disease, or biochemical response. These findings suggest that small dense LDL reflects superimposed metabolic dysfunction rather than intrinsic cholestatic liver disease and may help identify a metabolically driven atherogenic phenotype in contemporary PBC cohorts.
Publish Date 2026-08-18 03:51
Citation

Koky T, Drazilova S, Janicko M, Harhovsky M, Hubkova B, Tothova I, Rabajdova M, Marekova M, Jarcuska P. Small dense low-density lipoprotein in primary biliary cholangitis: Independent association with metabolic syndrome. World J Hepatol 2026; 18(8): 124436

URL https://www.wjgnet.com/1948-5182/full/v18/i8/124436.htm
DOI https://doi.org/10.4254/wjh.124436
Full Article (PDF) WJH-18-124436-with-cover.pdf
STROBE Statement 124436-STROBE-statement.pdf
Manuscript File 124436_Auto_Edited_005458.docx
Answering Reviewers 124436-answering-reviewers.pdf
Audio Core Tip 124436-audio.mp3
Biostatistics Review Certificate 124436-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 124436-conflict-of-interest-statement.pdf
Copyright License Agreement 124436-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 124436-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 124436-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 124436-non-native-speakers.pdf
Peer-review Report 124436-peer-reviews.pdf
Scientific Misconduct Check 124436-scientific-misconduct-check.png
Scientific Editor Work List 124436-scientific-editor-work-list.pdf
CrossCheck Report 124436-crosscheck-report.pdf