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Articles Published Processes
10/21/2026 2:09:40 AM | Browse: 1 | Download: 0
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Received |
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2026-06-17 02:17 |
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Peer-Review Started |
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2026-06-17 02:18 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-20 06:40 |
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Revised |
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2026-07-29 19:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-09-10 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-10 10:05 |
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Articles in Press |
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2026-09-10 10:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-10 09:52 |
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Publish the Manuscript Online |
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2026-10-21 02:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Hyperammonemia as a potential contributor to fatigue in metabolic dysfunction-associated steatotic liver disease: A mechanistic review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anna F Sheptulina, Julia A Golubeva, Diana L Valeeva, Anton R Kiselev and Oksana M Drapkina |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Work of National Medical Research Center for Therapy and Preventive Medicine According to the State Assignment of the Ministry of Health of the Russian Federation |
126020116173-4 (2026-2028) |
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| Corresponding Author |
Anton R Kiselev, Head, Professor, Coordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, str. 3, Moscow 101990, Moskva, Russia. antonkis@list.ru |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Hyperammonemia; Fatigue; Urea cycle; Sarcopenia; Mediterranean diet; Physical activity |
| Core Tip |
Hyperammonemia may develop in precirrhotic metabolic dysfunction-associated steatotic liver disease (MASLD) as a consequence of impaired ureagenesis associated with reduced expression and activity of urea cycle enzymes, together with alterations in glutamine metabolism. Current evidence suggests that ammonia may contribute to both central and peripheral fatigue through interconnected mechanisms involving neuroinflammation, impaired neurotransmission, mitochondrial dysfunction, oxidative stress, and skeletal muscle impairment. However, most available evidence originates from experimental studies, whereas direct clinical evidence in patients with MASLD remains limited. Although dietary factors, skeletal muscle status, and physical activity may influence ammonia homeostasis, their specific role in hyperammonemia in MASLD remains uncertain and should be regarded as hypothesis-generating. A better understanding of ammonia metabolism may facilitate the development of targeted strategies for fatigue management in MASLD. |
| Publish Date |
2026-10-21 02:09 |
| Citation |
Sheptulina AF, Golubeva JA, Valeeva DL, Kiselev AR, Drapkina OM. Hyperammonemia as a potential contributor to fatigue in metabolic dysfunction-associated steatotic liver disease: A mechanistic review. World J Hepatol 2026; 18(10): 124519
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i10/124519.htm |
| DOI |
https://doi.org/10.4254/wjh.124519 |
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