Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	12454
Country	Greece

Received	2014-07-09 17:41
Peer-Review Started	2014-07-09 17:50
First Decision by Editorial Office Director
Return for Revision	2014-11-03 08:04
Revised	2014-11-19 00:31
Publication Fee Transferred
Second Decision by Editor	2015-05-07 09:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-05-18 16:54
Articles in Press	2015-05-18 16:55
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-21 10:58
Publish the Manuscript Online	2015-08-08 13:26

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Primary biliary cirrhosis: From bench to bedside
Manuscript Source	Invited Manuscript
All Author List	Elias Kouroumalis and George Notas
Funding Agency and Grant Number
Corresponding Author	Elias Kouroumalis, MD, PhD, Professor, Department of Gastroenterology and Hepatology, University of Crete Medical School, PO BOX 2208, 71003 Heraklion, Crete, Greece. kouroum@med.uoc.gr
Key Words	Primary biliary cirrhosis; Innate immunity; Adaptive immunity; Ursodeoxycholate; Chemokines; Macrophages; Cytokines
Core Tip	Primary biliary cirrhosis (PBC) is a chronic non-suppurative destructive intrahepatic cholangitis leading to cirrhosis of largely unknown pathophysiology. We examined the epidemiological and geoepidemiological data as well as the pathogenetic aspects of PBC. A novel pathogenetic theory unifying the accumulated clinical information with in vitro and in vivo data is formulated. A review of clinical manifestations and immunological and pathological diagnosis was presented. Treatment modalities, including the multiple mechanisms of action of ursodeoxycholate are discussed.
Publish Date	2015-08-08 13:26
Citation	Kouroumalis E, Notas G. Primary biliary cirrhosis: From bench to bedside. World J Gastrointest Phar­macol Ther 2015; 6(3): 32-58
URL	http://www.wjgnet.com/2150-5349/full/v6/i3/32.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v6.i3.32

Full Article (PDF)	WJGPT-6-32.pdf
Full Article (Word)	WJGPT-6-32.doc
Manuscript File	12454-Review.doc
Answering Reviewers	12454-Answering reviewers.pdf
Audio Core Tip	12454-Audio core tip.wma
Conflict-of-Interest Disclosure Form	12454-Conflict-of-interest statement.pdf
Copyright License Agreement	12454-Copyright assignment.pdf
Peer-review Report	12454-Peer-review(s).pdf
Scientific Misconduct Check	12454-Scientific misconduct check.pdf
Scientific Editor Work List	12454-Scientific editor work list.pdf