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Articles Published Processes
9/24/2026 6:23:42 AM | Browse: 0 | Download: 0
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Received |
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2026-06-22 07:11 |
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Peer-Review Started |
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2026-06-22 07:11 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-09 08:55 |
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Revised |
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2026-07-18 14:18 |
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Publication Fee Transferred |
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2026-07-29 01:52 |
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Second Decision by Editor |
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2026-09-04 06:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-18 10:32 |
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Articles in Press |
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2026-09-18 10:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-21 00:28 |
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Publish the Manuscript Online |
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2026-09-24 06:23 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Yang, Jin-Long Zhong and Jia-Yuan Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 2024 Jinshan District Health Special Research Project - General Program |
JSKJ-KTMS-2024-02 |
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| Corresponding Author |
Jia-Yuan Liu, Chief Physician, Deputy Director, Department of Thoracic Surgery, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. ljyuan1985@163.com |
| Key Words |
Lung cancer; MED12 mutation; Stemness; CD8+ T; Notch signaling |
| Core Tip |
Mediator complex subunit 12 mutation in lung cancer cells activates Notch signaling, which concurrently promotes cancer stemness - characterized by enhanced sphere formation and increased ALDH1+ cells - and induces immune evasion via upregulation of surface programmed death ligand-1 on tumor cells. This leads to impaired CD8+ T cell chemotaxis, reduced release of effector molecules (interferon-γ, tumor necrosis factor-α, perforin, granzyme-B), and increased programmed cell death 1 expression. Notch inhibitor DAPT reverses these pro-tumor effects. |
| Publish Date |
2026-09-24 06:23 |
| Citation |
Yang Y, Zhong JL, Liu JY. MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer. World J Stem Cells 2026; 18(9): 124540
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i9/124540.htm |
| DOI |
https://doi.org/10.4252/wjsc.124540 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
