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Articles Published Processes
5/8/2015 2:17:00 PM | Browse: 1299 | Download: 1942
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Received |
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2014-07-10 08:53 |
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Peer-Review Started |
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2014-07-10 10:00 |
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To Make the First Decision |
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2014-10-28 14:30 |
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Return for Revision |
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2014-10-29 17:52 |
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Revised |
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2015-01-06 00:00 |
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Second Decision |
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2015-01-14 08:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-01-20 16:44 |
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Articles in Press |
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2015-01-20 16:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-09 17:48 |
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Publish the Manuscript Online |
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2015-05-08 14:17 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Minireviews |
| Article Title |
African origins and chronic kidney disease susceptibility in the HIV era
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alex N Kasembeli, Raquel Duarte, Michèle Ramsay and Saraladevi Naicker |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH Fogarty International Center Grant |
1D43TW008330-01A1 |
| Millennium Promise Award, Non-communicable Chronic Diseases Leadership Training Program |
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| NHLS Research Trust, Division of Nephrology Research Fund, University of the Witwatersrand |
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| Johannesburg and FRC Individual grant, University of the Witwatersrand, Johannesburg |
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| Corresponding Author |
Saraladevi Naicker, Professor, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa. Saraladevi.Naicker@wits.ac.za |
| Key Words |
Chronic kidney disease; Human immunodeficiency virus; Human immunodeficiency virus-associated nephropathy; African ancestry; Genetics; APOL1; MYH9 |
| Core Tip |
There are striking ethnic differences in the prevalence of chronic kidney disease CKD, including human immunodeficiency virus (HIV)-associated nephropathy (HIVAN), in people of African ancestry suggestive of genetic predisposition. The APOL1 G1 and G2 alleles are more strongly associated with the risk for HIVAN than the previously reported MYH9 E1 risk haplotype in individuals of African ancestry in United States and African studies. The high prevalence of HIVAN among individuals of African ancestry could be a result of high frequencies of APOL1 risk variants as well as the prevalence of HIV-1 subtypes and modifying factors or second hits underlying the pathogenesis of kidney disease. |
| Publish Date |
2015-05-08 14:17 |
| Citation |
Kasembeli AN, Duarte R, Ramsay M, Naicker S. African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era. World J Nephrol 2015; 4(2): 295-306 |
| URL |
http://www.wjgnet.com/2220-6124/full/v4/i2/295.htm |
| DOI |
http://dx.doi.org/10.5527/wjn.v4.i2.295 |
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