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5/8/2015 2:17:00 PM | Browse: 571 | Download: 751
Publication Name World Journal of Nephrology
Manuscript ID 12457
Country/Territory South Africa
2014-07-10 08:53
Peer-Review Started
2014-07-10 10:00
To Make the First Decision
2014-10-28 14:30
Return for Revision
2014-10-29 17:52
2015-01-06 00:00
Second Decision
2015-01-14 08:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-01-20 16:44
Articles in Press
2015-01-20 16:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-09 17:48
Publish the Manuscript Online
2015-05-08 14:17
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics and Heredity
Manuscript Type Minireviews
Article Title African origins and chronic kidney disease susceptibility in the HIV era
Manuscript Source Invited Manuscript
All Author List Alex N Kasembeli, Raquel Duarte, Michèle Ramsay and Saraladevi Naicker
Funding Agency and Grant Number
Funding Agency Grant Number
NIH Fogarty International Center Grant 1D43TW008330-01A1
Millennium Promise Award, Non-communicable Chronic Diseases Leadership Training Program
NHLS Research Trust, Division of Nephrology Research Fund, University of the Witwatersrand
Johannesburg and FRC Individual grant, University of the Witwatersrand, Johannesburg
Corresponding author Saraladevi Naicker, Professor, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa. Saraladevi.Naicker@wits.ac.za
Keywords Chronic kidney disease; Human immunodeficiency virus; Human immunodeficiency virus-associated nephropathy; African ancestry; Genetics; APOL1; MYH9
Core Tip There are striking ethnic differences in the prevalence of chronic kidney disease CKD, including human immunodeficiency virus (HIV)-associated nephropathy (HIVAN), in people of African ancestry suggestive of genetic predisposition. The APOL1 G1 and G2 alleles are more strongly associated with the risk for HIVAN than the previously reported MYH9 E1 risk haplotype in individuals of African ancestry in United States and African studies. The high prevalence of HIVAN among individuals of African ancestry could be a result of high frequencies of APOL1 risk variants as well as the prevalence of HIV-1 subtypes and modifying factors or second hits underlying the pathogenesis of kidney disease.
Publish Date 2015-05-08 14:17
Citation Kasembeli AN, Duarte R, Ramsay M, Naicker S. African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era. World J Nephrol 2015; 4(2): 295-306
Url http://www.wjgnet.com/2220-6124/full/v4/i2/295.htm
DOI http://dx.doi.org/10.5527/wjn.v4.i2.295
Full Article (PDF) WJN-4-295.pdf
Full Article (Word) WJN-4-295.doc
Manuscript File 12457-Review.doc
Answering Reviewers 12457-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 12457-Conflict-of-interest statement.pdf
Copyright License Agreement 12457-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140709212028.jpg
Peer-review Report 12457-Peer review(s).pdf
Scientific Misconduct Check 12457-CrossCheck.jpg
Scientific Editor Work List 12457-Scientific editor work list.pdf