BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/20/2026 3:29:01 AM | Browse: 1 | Download: 2
 |
Received |
|
2026-06-23 02:27 |
|
Peer-Review Started |
|
2026-06-23 02:27 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-07-22 06:20 |
|
Revised |
|
2026-08-04 03:18 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-09-17 08:52 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-09-17 09:19 |
|
Articles in Press |
|
2026-09-17 09:19 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-09-18 03:53 |
|
Publish the Manuscript Online |
|
2026-09-20 03:29 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of Kalanchoe pinnata, exercise, and stimulation on neuroinflammation, redox homeostasis, and neuropathic pain in a Wistar-rat model
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Olamide Wilson Fasakin, Ayoola Awosika, Funmilayo Mercy Ojo and Ayodeji Samuel Boboye |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Ayoola Awosika, MD, Department of Family and Community Medicine, University of Illinois College of Medicine Peoria, 1 Illini Drive, Bloomington, IL 61601, United States. ayoolaawosika@yahoo.com |
| Key Words |
Neuropathic pain; Prefrontal cortex; Kalanchoe pinnata; Treadmill exercise; Vagus nerve stimulation |
| Core Tip |
Neuropathic pain is a persistent, treatment-resistant condition driven not only by peripheral nerve injury but also by maladaptive neuroplasticity in central pain-regulatory networks. Evidence increasingly points to dysfunction in the prefrontal cortex, a vital area for top-down control of pain, emotions, and autonomic functions, as a key factor in maintaining pain hypersensitivity. This study examined the combined effects of Kalanchoe pinnata, treadmill exercise, and vagus nerve stimulation on neuroinflammation, redox homeostasis, and neuropathic pain in a rat model. This study shows that combining Kalanchoe pinnata, treadmill exercise, and vagus nerve stimulation offers better relief for neuropathic pain than any single treatment or drug. This triple therapy activates the nuclear factor erythroid 2-related factor 2/heme-oxygenase 1 pathway, reduces neuroinflammation, restores neuroplasticity, decreases cell death, and normalizes neurotransmission by correcting molecular imbalances in the prefrontal cortex. |
| Publish Date |
2026-09-20 03:29 |
| Citation |
Fasakin OW, Awosika A, Ojo FM, Boboye AS. Effects of Kalanchoe pinnata, exercise, and stimulation on neuroinflammation, redox homeostasis, and neuropathic pain in a Wistar-rat model. World J Exp Med 2026; 16(3): 124614
|
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i3/124614.htm |
| DOI |
https://doi.org/10.5493/wjem.124614 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
