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Articles Published Processes
10/26/2026 6:39:38 AM | Browse: 0 | Download: 0
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Received |
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2026-06-23 06:46 |
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Peer-Review Started |
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2026-06-23 06:46 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-06 11:30 |
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Revised |
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2026-07-19 09:04 |
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Publication Fee Transferred |
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2026-08-02 10:54 |
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Second Decision by Editor |
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2026-09-07 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-14 08:40 |
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Articles in Press |
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2026-10-14 08:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-21 00:41 |
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Publish the Manuscript Online |
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2026-10-26 06:39 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Human bone marrow-derived mesenchymal stem cells alleviate fluoxetine-resistant depression-like behaviors in mice by multi-target effects in the hippocampus
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Liu, Jian-Fei Wu, Mao-Ya Xu, Ji Kang, An-Hong Ye, Bo Liu and Ke-Zhi Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zigong Key Science and Technology Plan (Collaborative Innovation Project of Zigong Institute of Brain Sciences) |
2025NKY0104, 2025NKY0201, 2025NKY0105 |
| Health Commission of Zigong High-Level Talent Development Project |
WJW-GCCRC025 |
| Zigong Key Science and Technology Plan (Collaborative Innovation Project of Zigong Institute of Brain Sciences) |
2024-NKY-01-04 |
| Collaborative Innovation Project of Zigong Integrated Traditional Chinese and Western Medicine Research Institute |
2025ZXY0206 |
| Health Commission of Sichuan Province Medical Science and Technology Program |
25QNMP018 |
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| Corresponding Author |
Bo Liu, PhD, Center for Psychiatry Research, Zigong Mental Health Center, No. 666 Gongshu Road, Gongjing District, Zigong 643020, Sichuan Province, China. liubo2511@163.com |
| Key Words |
Major depressive disorder; Treatment-resistant depression; Chronic unpredictable restraint stress; Corticosterone; Fluoxetine; Human bone marrow-derived mesenchymal stem cells; Neuroinflammation; Neurogenesis; Brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling |
| Core Tip |
We established a mouse model of fluoxetine-resistant depression (FRD) by combining chronic unpredictable restraint stress with corticosterone administration. Systemic administration of human bone marrow-derived mesenchymal stem cells (hBMSCs) exerted robust antidepressant-like effects through multiple mechanisms, including suppression of hippocampal neuroinflammation, restoration of astrocytic integrity, protection of neuronal survival, and promotion of adult neurogenesis. These effects were associated with reactivation of the brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling pathway. hBMSCs did not engraft in the brain, suggesting paracrine-mediated actions. Our findings support the use of hBMSCs as a promising multi-target therapeutic strategy for FRD, an early stage of treatment-resistant depression. |
| Publish Date |
2026-10-26 06:39 |
| Citation |
Liu Y, Wu JF, Xu MY, Kang J, Ye AH, Liu B, Liu KZ. Human bone marrow-derived mesenchymal stem cells alleviate fluoxetine-resistant depression-like behaviors in mice by multi-target effects in the hippocampus. World J Stem Cells 2026; 18(10): 124640
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i10/124640.htm |
| DOI |
https://doi.org/10.4252/wjsc.124640 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
