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Articles Published Processes
10/21/2026 2:09:38 AM | Browse: 1 | Download: 0
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Received |
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2026-06-24 07:38 |
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Peer-Review Started |
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2026-06-24 07:38 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-23 07:18 |
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Revised |
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2026-08-05 04:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-09-17 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-17 09:37 |
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Articles in Press |
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2026-09-17 09:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-30 14:49 |
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Publish the Manuscript Online |
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2026-10-21 02:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Autoimmune hepatitis in the context of systemic lupus erythematosus: A narrative review of overlap syndrome and lupus-associated hepatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Abdelwahap Elghezewi and Mujtaba Mohamed |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdelwahap Elghezewi, Academic Fellow, FACG, FACP, Section of Gastroenterology, Marshall University, 249 15th Street, Huntington, WV 25701, United States. elghezewia@marshall.edu |
| Key Words |
Autoimmune hepatitis; Systemic lupus erythematosus; Overlap syndrome; Lupus hepatitis; autoantibodies; Liver biopsy; Immunopathogenesis |
| Core Tip |
Liver enzyme abnormalities affect up to 60% of patients with systemic lupus erythematosus, yet true autoimmune hepatitis (AIH)-systemic lupus erythematosus overlap is rare and often over-diagnosed because antinuclear antibodies and hypergammaglobulinemia inflate International AIH Group scores. AIH is cell-mediated and can progress to cirrhosis, whereas lupus hepatitis is immune complex-mediated with complement consumption and an excellent prognosis. Liver biopsy with C1q immunofluorescence, anti-smooth muscle and anti-soluble liver antigen/liver-pancreas antibodies, and complement levels are key discriminators. Mycophenolate mofetil is the preferred dual-purpose agent; validated overlap-specific criteria remain needed. |
| Publish Date |
2026-10-21 02:09 |
| Citation |
Elghezewi A, Mohamed M. Autoimmune hepatitis in the context of systemic lupus erythematosus: A narrative review of overlap syndrome and lupus-associated hepatitis. World J Hepatol 2026; 18(10): 124793
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i10/124793.htm |
| DOI |
https://doi.org/10.4254/wjh.124793 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
