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Publication Name World Journal of Orthopedics
Manuscript ID 124852
Country China
Received
2026-06-26 08:55
Peer-Review Started
2026-06-26 08:55
First Decision by Editorial Office Director
Return for Revision
2026-07-28 03:38
Revised
2026-08-08 16:16
Publication Fee Transferred
2026-08-20 10:24
Second Decision by Editor
2026-08-31 03:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-08-31 08:47
Articles in Press
2026-08-31 08:47
Edit the Manuscript by Language Editor
2026-09-11 00:15
Typeset the Manuscript
2026-10-10 03:32
Publish the Manuscript Online
2026-10-16 05:20
ISSN 2218-5836 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Systematic Reviews
Article Title Associations of estrogen vs testosterone replacement therapy with complications after total joint arthroplasty: A systematic review
Manuscript Source Unsolicited Manuscript
All Author List Xing-Chun Huang, Zhen-Kun Duan, Yu-Ji Zhang, Hua-Jie Huang, Ming Ma, Cong Tian, Jin-Min Liu and Bin Geng
ORCID
Author(s) ORCID Number
Xing-Chun Huang http://orcid.org/0009-0003-7537-0823
Bin Geng http://orcid.org/0000-0002-1505-3645
Funding Agency and Grant Number
Corresponding Author Bin Geng, MD, Department of Orthopaedics, The Second Hospital of Lanzhou University, Lanzhou University Second Hospital, #82 Cuiyingmen, Lanzhou, Gansu, People's Republic of China, Lanzhou 730030, Gansu Province, China. cxxxf@foxmail.com
Key Words Total joint arthroplasty; Hormone replacement therapy; Estrogen replacement therapy; Testosterone replacement therapy; Postoperative complications
Core Tip This study compared the associations of estrogen replacement therapy (ERT) and testosterone replacement therapy (TRT) with both medical and implant-related complications after total joint arthroplasty. The results indicate that existing clinical evidence on perioperative ERT remains contradictory, while TRT may be associated with elevated odds of periprosthetic joint infection and acute kidney injury. Nevertheless, these findings are inconsistent. Given substantial heterogeneity and the observational design of the included studies, no definitive conclusions can be drawn; prospective research is urgently needed to optimize perioperative hormone management.
Publish Date 2026-10-16 05:20
Citation

Huang XC, Duan ZK, Zhang YJ, Huang HJ, Ma M, Tian C, Liu JM, Geng B. Associations of estrogen vs testosterone replacement therapy with complications after total joint arthroplasty: A systematic review. World J Orthop 2026; 17(10): 124852

URL https://www.wjgnet.com/2218-5836/full/v17/i10/124852.htm
DOI https://doi.org/10.5312/wjo.124852
Full Article (PDF) WJO-17-124852-with-cover.pdf
PRISMA 2009 Checklist 124852-PRISMA-2009-Checklist.pdf
Manuscript File 124852_Auto_Edited_071620.docx
Answering Reviewers 124852-answering-reviewers.pdf
Audio Core Tip 124852-audio.mp3
Biostatistics Review Certificate 124852-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 124852-conflict-of-interest-statement.pdf
Copyright License Agreement 124852-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 124852-non-native-speakers.pdf
Supplementary Material 124852-supplementary-material.pdf
Peer-review Report 124852-peer-reviews.pdf
Scientific Misconduct Check 124852-scientific-misconduct-check.png
CrossCheck Report 124852-crosscheck-report.pdf