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Articles Published Processes
8/26/2026 5:34:15 AM | Browse: 1 | Download: 0
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Received |
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2026-06-26 06:12 |
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Peer-Review Started |
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2026-06-26 06:15 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-06-29 05:42 |
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Revised |
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2026-07-13 04:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-20 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-20 09:13 |
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Articles in Press |
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2026-08-20 09:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-24 01:00 |
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Publish the Manuscript Online |
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2026-08-26 05:34 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Cardiovascular aging as a modifiable biological process: Mechanisms, clinical phenotypes, and translational opportunities
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qing Liu, Yi-Fei Wang, Yu Geng, Ping Zhang and Ting-Ting Lv |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ting-Ting Lv, Associate Research Scientist, Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Changping District, Beijing 102218, China. lvtingting0616@163.com |
| Key Words |
Cardiovascular aging; Geroscience; Hallmarks of aging; Translational medicine; Biomarkers; Intervention |
| Core Tip |
This review synthesizes current evidence that cardiovascular aging is driven by interconnected hallmarks: Cellular senescence, mitochondrial dysfunction, epigenetic remodeling, telomere attrition, and impaired proteostasis which converge on atherosclerosis, heart failure with preserved ejection fraction, hypertension, and arrhythmia. We highlight emerging assessment tools including imaging-based indices, circulating biomarkers, and epigenetic clocks for quantifying biological age, and critically evaluate geroprotective strategies ranging from lifestyle modification to senotherapeutics and nicotinamide adenine dinucleotide/mechanistic target of rapamycin modulation. Bridging geroscience principles with cardiovascular medicine, this review positions cardiovascular aging as a clinically modifiable target for promoting healthy longevity. |
| Publish Date |
2026-08-26 05:34 |
| Citation |
Liu Q, Wang YF, Geng Y, Zhang P, Lv TT. Cardiovascular aging as a modifiable biological process: Mechanisms, clinical phenotypes, and translational opportunities. World J Cardiol 2026; 18(8): 124876
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i8/124876.htm |
| DOI |
https://doi.org/10.4330/wjc.124876 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
