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Publication Name World Journal of Stem Cells
Manuscript ID 124937
Country China
Received
2026-06-29 08:31
Peer-Review Started
2026-06-29 08:31
First Decision by Editorial Office Director
Return for Revision
2026-07-15 07:18
Revised
2026-08-07 08:15
Publication Fee Transferred
2026-09-08 13:45
Second Decision by Editor
2026-09-21 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-30 07:45
Articles in Press
2026-09-30 07:45
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-10-20 09:24
Publish the Manuscript Online
2026-10-26 06:39
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Review
Article Title Stem cell therapy for endocrine and metabolic disorders
Manuscript Source Unsolicited Manuscript
All Author List Dong-Qing Lv, Ming Xu, Sen-Jie Li, Shu-Qing Jin, Qin-Hao Liu, Jing Zhou, Jia-Ning Lv, Yun-Feng Liu and Yi Zhang
ORCID
Author(s) ORCID Number
Yun-Feng Liu http://orcid.org/0000-0003-2826-5804
Yi Zhang http://orcid.org/0000-0003-0305-3127
Funding Agency and Grant Number
Funding Agency Grant Number
Shanxi Province Basic Research Program 202303021212321
Shanxi Province Higher Education “Billion Project” Science and Technology Guidance Project BYJL024
Shanxi Provincial Health Commission 2026 Strengthening Basic Disciplines Plan for Science and Technology Advancing Medical Innovation Program 2026QJGC010
Corresponding Author Yun-Feng Liu, MD, PhD, Professor, Department of Endocrinology, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030000, Shanxi Province, China. nectarliu@163.com
Key Words Stem cell therapy; Diabetes; Hypothyroidism; Hypopituitarism; Primary adrenal insufficiency; Osteoporosis
Core Tip This review provides the first systematic comparison of pluripotent and mesenchymal stem cell strategies across major endocrine and metabolic disorders, diabetes, hypothyroidism, hypopituitarism, adrenal insufficiency, and osteoporosis. We establish a clear functional framework: Pluripotent stem cells-mediated cell replacement is applicable to diseases characterized by irreversible cell loss, whereas mesenchymal stem cell-mediated anti-inflammatory and immunomodulatory actions are applicable to inflammation- or immune-driven conditions. We also identify translational barriers and propose actionable solutions, offering a roadmap from proof-of-concept toward clinical practice.
Publish Date 2026-10-26 06:39
Citation

Lv DQ, Xu M, Li SJ, Jin SQ, Liu QH, Zhou J, Lv JN, Liu YF, Zhang Y. Stem cell therapy for endocrine and metabolic disorders. World J Stem Cells 2026; 18(10): 124937

URL https://www.wjgnet.com/1948-0210/full/v18/i10/124937.htm
DOI https://doi.org/10.4252/wjsc.124937
Full Article (PDF) WJSC-18-124937-with-cover.pdf
Manuscript File 124937_Auto_Edited_013536.docx
Answering Reviewers 124937-answering-reviewers.pdf
Audio Core Tip 124937-audio.mp3
Conflict-of-Interest Disclosure Form 124937-conflict-of-interest-statement.pdf
Copyright License Agreement 124937-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 124937-non-native-speakers.pdf
Supplementary Material 124937-supplementary-material.pdf
Peer-review Report 124937-peer-reviews.pdf
Scientific Misconduct Check 124937-scientific-misconduct-check.png
CrossCheck Report 124937-crosscheck-report.pdf