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Articles Published Processes
9/3/2026 2:08:37 AM | Browse: 0 | Download: 0
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Received |
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2026-06-29 03:22 |
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Peer-Review Started |
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2026-06-29 03:22 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-21 11:46 |
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Revised |
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2026-07-30 10:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-31 03:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-31 08:47 |
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Articles in Press |
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2026-08-31 08:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-01 01:42 |
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Publish the Manuscript Online |
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2026-09-03 02:08 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Hepatic exposome as an emerging contributor to metabolic dysfunction-associated steatotic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ahmed Salman, Ahmed Elewa, Ahmad Marwan and Mohamed A Salman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ahmed Salman, FRACP, FRCP, Department of Internal Medicine, Faculty of Medicine, Cairo University, Zahraa El Maadi, Abrag Degla Masr, Building 46, Fourth Floor, Apartment 41, Near to Kuwaiti Mosque, 11742, Cairo 12111, Egypt. awea844@gmail.com |
| Key Words |
Exposome; Steatotic liver disease; Metabolic dysfunction-associated steatotic liver disease; Per- and polyfluoroalkyl substances; Microplastics; Endocrine-disrupting chemicals; Environmental pollutants; Hepatocellular carcinoma; Environmental hepatology |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease is typically a result of overnutrition and metabolic syndrome; the phenomenon of lean disease and its increasing prevalence remain inadequately elucidated. This review analyzes the hepatic exposome, focusing on environmental chemicals such as per- and polyfluoroalkyl substances, phthalates, bisphenols, persistent organic pollutants, toxic metals, and air pollution as potential modifiable factors contributing to steatosis, steatohepatitis, fibrosis, and hepatocellular carcinoma, while also noting that micro- and nanoplastics remain an emerging and unverified exposure. We incorporated shared mechanisms, human and experimental evidence assessed by strength, sex-specific susceptibility, and the tools necessary to implement environmental hepatology in practice. |
| Publish Date |
2026-09-03 02:08 |
| Citation |
Salman A, Elewa A, Marwan A, Salman MA. Hepatic exposome as an emerging contributor to metabolic dysfunction-associated steatotic liver disease. World J Transl Med 2026; 12(3): 124965
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| URL |
https://www.wjgnet.com/2220-6132/full/v12/i3/124965.htm |
| DOI |
https://doi.org/10.5528/wjtm.124965 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
