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Articles Published Processes
3/20/2015 10:48:00 AM | Browse: 983 | Download: 971
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Received |
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2014-07-12 11:01 |
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Peer-Review Started |
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2014-07-12 15:11 |
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To Make the First Decision |
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2014-09-24 11:20 |
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Return for Revision |
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2014-09-24 21:16 |
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Revised |
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2014-10-01 00:55 |
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Second Decision |
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2014-11-10 15:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-10 15:57 |
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Articles in Press |
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2014-11-10 15:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-02-12 10:39 |
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Publish the Manuscript Online |
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2015-03-20 10:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Martha L Arango-Rodriguez, Fernando Ezquer, Marcelo Ezquer and Paulette Conget |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| FONDECYT to Paulette Conget |
1130760 |
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| Corresponding Author |
Paulette Conget, PhD, Center for Regenerative Medicine, School of Medicine Clínica Alemana Universidad del Desarrollo, Av. Las Condes 12438, Lo Barnechea, Santiago 7710162, Chile. pconget@udd.cl |
| Key Words |
Cancer; Infection; Mesenchymal stem cells; Therapy; Biosafety |
| Core Tip |
Mesenchymal stem cells (MSCs) derived from different origins have recently received much attention as potential therapeutic. However, such cells also appear to have essential functions in building and supporting tumor microenvironments. Here, we review the effect of MSCs on tumor establishment, as also susceptibility to infection and its progression. The literature reveals incongruity regarding the impact of MSCs on the development of cancer and infection; such paradoxical effect might be attributed to differences in isolation and expansion conditions, the source and dose of the cells, the administration route and its timing and host characteristics. MSCs immunomodulatory potential seems to be the leading mechanism responsible for such effects. |
| Publish Date |
2015-03-20 10:47 |
| Citation |
Arango-Rodriguez ML, Ezquer F, Ezquer M, Conget P. Could cancer and infection be adverse effects of mesenchymal stromal cell therapy? World J Stem Cells 2015; 7(2): 408-417 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i2/408.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i2.408 |
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