| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Han Zheng, Yang-Yang Wang, Shu-Chang Wang, Chao-Jie Wang, Yan-Ying Shen, Jian-Zhi Cui, Shi-Meng Liu, Ye-Hao Zhang, Xue-Qin Zeng and En-Hao Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Shanghai Municipality |
23ZR1439400 |
| the National Natural Science Foundation of China |
82103348 |
| the Fundamental Research Funds for the Central Universities |
YG2023QNA10 |
|
| Corresponding Author |
En-Hao Zhao, Chief Physician, MD, PhD, Professor, Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China. zhaoenhao@renji.com |
| Key Words |
Gastric adenocarcinoma; Poorly cohesive carcinoma; Signet ring cell carcinoma; Pathological classification; Prognosis; Retrospective cohort study |
| Core Tip |
This single-center retrospective cohort study evaluated poorly cohesive gastric carcinoma and its subtypes, defined by the proportions of signet ring cell (SRC) and poorly cohesive carcinoma-not otherwise specified (PCC-NOS) components, and identified distinct clinicopathological and immunohistochemical profiles. Although the SRC-dominant group was associated with superior overall survival, this prognostic advantage disappeared after propensity score matching, whereas the PCC-NOS-dominant group was potentially associated with microsatellite instability and programmed death protein ligand 1 expression. These findings emphasize the need for further investigation and comprehensive evaluation of poorly cohesive carcinoma and its subtypes. |
| Publish Date |
2026-10-22 02:34 |
| Citation |
Zheng YH, Wang YY, Wang SC, Wang CJ, Shen YY, Cui JZ, Liu SM, Zhang YH, Zeng XQ, Zhao EH. Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage. World J Clin Oncol 2026; 17(10): 125097
|
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i10/125097.htm |
| DOI |
https://doi.org/10.5306/wjco.125097 |
