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Articles Published Processes
3/16/2015 6:04:00 PM | Browse: 970 | Download: 1185
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Received |
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2014-07-13 12:42 |
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Peer-Review Started |
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2014-07-13 20:40 |
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To Make the First Decision |
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2014-08-15 12:17 |
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Return for Revision |
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2014-08-20 13:09 |
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Revised |
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2014-08-21 20:20 |
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Second Decision |
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2014-10-21 17:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-21 18:06 |
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Articles in Press |
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2014-10-21 18:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-29 22:37 |
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Typeset the Manuscript |
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2015-03-05 09:29 |
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Publish the Manuscript Online |
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2015-03-16 18:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Decaprenyl diphosphate synthase subunit 2 as a prognosis factor in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Huang, Fei Gao, Kang Li, Wen Wang, Ya-Rou Lai, Shao-Hui Tang and Dong-Hua Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundamental Research Funds for the First Clinical College of Jinan University |
2014110 |
| National Natural Science Foundation of China |
81401973 |
| Fundamental Research Funds for the Central Universities of China |
21614304 |
| Medical Scientific Research Foundation of Guangdong Province of China |
B2014222 |
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| Corresponding Author |
Wei Huang, Professor, Department of Gastroenterology, the First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Guangdong Province, Guangzhou 510630, China. thuangw@163.com |
| Key Words |
Decaprenyl diphosphate synthase subunit 2; Hepatocellular carcinoma; Tumor suppressor |
| Core Tip |
We found that decaprenyl diphosphate synthase subunit 2 (PDSS2) was frequently downregulated in primary hepatocellular carcinoma (HCC), and the level of expression was markedly lower in poorly differentiated cancer samples compared with well-differentiated tumor tissues. Furthermore, the expression of PDSS2 was inversely correlated with clinical stage. Overexpression of PDSS2 in HepG2 cells decreased cell proliferation and induced G1-phase cell cycle arrest and apoptosis in human HCC cells. Moreover, PDSS2 reduced epithelial-mesenchymal transition in HCC. |
| Publish Date |
2015-03-16 18:04 |
| Citation |
Huang W, Gao F, Li K, Wang W, Lai YR, Tang SH, Yang DH. Decaprenyl diphosphate synthase subunit 2 as a prognosis factor in hepatocellular carcinoma. World J Gastroenterol 2015; 21(10): 3055-3065 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i10/3055.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i10.3055 |
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