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Articles Published Processes
8/26/2026 5:34:15 AM | Browse: 1 | Download: 0
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Received |
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2026-07-02 05:53 |
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Peer-Review Started |
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2026-07-02 05:53 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-17 06:06 |
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Revised |
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2026-07-30 07:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-20 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-20 09:16 |
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Articles in Press |
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2026-08-20 09:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-24 01:00 |
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Publish the Manuscript Online |
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2026-08-26 05:34 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Cardiac xenotransplantation: From imagination to achievable practice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cai-Hong Wan, Bo-Yi Zhou and Yu-Long Guan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yu-Long Guan, MD, Professor, Department of Extracorporeal Circulation, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100037 Beijing, China, No 167, Beilishi Road, Xicheng District, Beijing 100037, China, Beijing 100037, China. guanyulong2014@163.com |
| Key Words |
Heart failure; Heart transplantation; Xenotransplantation; Genetic engineering; Pig |
| Core Tip |
Cardiac xenotransplantation has advanced from the failed animal-heart attempts of 1964-1984 to two landmark first-in-human compassionate-use transplants of 10-gene-edited pig hearts in 2022 and 2023. Although both recipients died within 40-60 days, these proof-of-concept cases defined the key remaining barriers-antibody-mediated injury, porcine viral reactivation, and diastolic dysfunction-that must be resolved before gene-edited pig hearts may be explored in the further clinical trials and act as one of reliable and effective means for the treatment of end-stage heart failure. |
| Publish Date |
2026-08-26 05:34 |
| Citation |
Wan CH, Zhou BY, Guan YL. Cardiac xenotransplantation: From imagination to achievable practice. World J Cardiol 2026; 18(8): 125199
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i8/125199.htm |
| DOI |
https://doi.org/10.4330/wjc.125199 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
