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2/11/2015 4:38:00 PM | Browse: 894 | Download: 1232
Publication Name World Journal of Gastroenterology
Manuscript ID 12522
Country/Territory China
Received
2014-07-13 11:59
Peer-Review Started
2014-07-13 12:02
To Make the First Decision
2014-08-15 12:01
Return for Revision
2014-08-21 12:07
Revised
2014-09-17 14:38
Second Decision
2014-11-11 10:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-11 10:25
Articles in Press
2014-11-11 11:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-12-11 20:35
Typeset the Manuscript
2015-02-02 14:43
Publish the Manuscript Online
2015-02-11 16:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Randomized Clinical Trial
Article Title Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Jin-Shen Wang, Chang-Qing Jing, Ke-Shu Shan, Yue-Zhi Chen, Xiao-Bo Guo, Zhi-Xin Cao, Lin-Jun Mu, Li-Pan Peng, Ming-Liang Zhou and Le-Ping Li
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research Foundation of Shandong Province for Outstanding Young Scientist Award 2009GG20002037
Corresponding Author Le-Ping Li, MD, Department of Gastro­intestinal Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan 250021, Shandong Province, China. doctor@mail.sdu.edu.cn
Key Words Colorectal carcinoma; Immunohistochemical staining; Hypoxia-inducible factor-1α; Semaphorin 4D; Prognosis
Core Tip Although originally identified in the context of neurodevelopment, semaphorin 4D (Sema4D) is also important in angiogenesis. Sema4D is widely expressed in several types of malignant solid tumors. However, its function and expression in colorectal carcinoma are not understood. This study indicates that Sema4D expression is positively correlated with HIF-1α in colorectal carcinoma and that Sema4D is a novel indicator of poor prognosis for colorectal carcinoma patients. We expect that Sema4D could be used as a reliable tool to the early and accurate prediction of tumor recurrence, and it represents a potential therapeutic target for colorectal cancer patients.
Publish Date 2015-02-11 16:38
Citation Wang JS, Jing CQ, Shan KS, Chen YZ, Guo XB, Cao ZX, Mu LJ, Peng LP, Zhou ML, Li LP. Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma. World J Gastroenterol 2015; 21(7): 2191-2198
URL http://www.wjgnet.com/1007-9327/full/v21/i7/2191.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i7.2191
Full Article (PDF) WJG-21-2191.pdf
Full Article (Word) WJG-21-2191.doc
Manuscript File 12522-Review.doc
Answering Reviewers 12522-Answering reviewers.pdf
Copyright License Agreement 12522-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12522-Language certificate.pdf
Peer-review Report 12522-Peer reviews.pdf
Scientific Misconduct Check 12522-CrossCheck.jpg
Scientific Editor Work List 12522-Scientific editor work list.pdf