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Articles Published Processes
2/11/2015 4:38:00 PM | Browse: 1011 | Download: 1554
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Received |
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2014-07-13 11:59 |
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Peer-Review Started |
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2014-07-13 12:02 |
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To Make the First Decision |
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2014-08-15 12:01 |
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Return for Revision |
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2014-08-21 12:07 |
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Revised |
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2014-09-17 14:38 |
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Second Decision |
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2014-11-11 10:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-11 10:25 |
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Articles in Press |
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2014-11-11 11:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-11 20:35 |
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Typeset the Manuscript |
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2015-02-02 14:43 |
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Publish the Manuscript Online |
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2015-02-11 16:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Shen Wang, Chang-Qing Jing, Ke-Shu Shan, Yue-Zhi Chen, Xiao-Bo Guo, Zhi-Xin Cao, Lin-Jun Mu, Li-Pan Peng, Ming-Liang Zhou and Le-Ping Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Foundation of Shandong Province for Outstanding Young Scientist Award |
2009GG20002037 |
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| Corresponding Author |
Le-Ping Li, MD, Department of Gastrointestinal Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan 250021, Shandong Province, China. doctor@mail.sdu.edu.cn |
| Key Words |
Colorectal carcinoma; Immunohistochemical staining; Hypoxia-inducible factor-1α; Semaphorin 4D; Prognosis |
| Core Tip |
Although originally identified in the context of neurodevelopment, semaphorin 4D (Sema4D) is also important in angiogenesis. Sema4D is widely expressed in several types of malignant solid tumors. However, its function and expression in colorectal carcinoma are not understood. This study indicates that Sema4D expression is positively correlated with HIF-1α in colorectal carcinoma and that Sema4D is a novel indicator of poor prognosis for colorectal carcinoma patients. We expect that Sema4D could be used as a reliable tool to the early and accurate prediction of tumor recurrence, and it represents a potential therapeutic target for colorectal cancer patients. |
| Publish Date |
2015-02-11 16:38 |
| Citation |
Wang JS, Jing CQ, Shan KS, Chen YZ, Guo XB, Cao ZX, Mu LJ, Peng LP, Zhou ML, Li LP. Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma. World J Gastroenterol 2015; 21(7): 2191-2198 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i7/2191.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i7.2191 |
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