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9/18/2026 8:52:42 AM | Browse: 0 | Download: 0
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Received |
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2026-07-09 05:52 |
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Peer-Review Started |
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2026-07-09 05:52 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-05 05:57 |
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Revised |
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2026-08-05 09:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-09-04 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-04 10:24 |
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Articles in Press |
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2026-09-04 10:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-16 02:28 |
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Publish the Manuscript Online |
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2026-09-18 08:52 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Butterfly effect of oral frailty and sensory blurring: A complex systems framework for hip fracture vulnerability
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Takahiko Nagamine |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Takahiko Nagamine, MD, PhD, Professor Emeritus, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu 747-0066, Japan. tnagamine@outlook.com |
| Key Words |
Butterfly effect; Complex systems science; Descending pain inhibitory system; Hip fracture; Oral frailty; Sensory blurring |
| Core Tip |
We should stop thinking about hip fracture risk through a simple, straight line of just bone density and falls. Looking at the human body as a complex system, things like oral frailty and age-related nerve changes (descending pain inhibitory system dysfunction) are like tiny initial disturbances in a big, interconnected web. Through sensory blurring, bad nutrition, and muscle loss, these small issues feed into each other and grow larger over time. This is exactly like the “butterfly effect”, where a tiny change eventually causes a major storm — or in this case, a bad hip fracture. This new model shows why we need to focus on whole-body resilience instead of just single medical targets. |
| Publish Date |
2026-09-18 08:52 |
| Citation |
Nagamine T. Butterfly effect of oral frailty and sensory blurring: A complex systems framework for hip fracture vulnerability. World J Clin Cases 2026; 14(26): 125278
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| URL |
https://www.wjgnet.com/2307-8960/full/v14/i26/125278.htm |
| DOI |
https://doi.org/10.12998/wjcc.125278 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
