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Articles Published Processes
9/24/2026 6:23:44 AM | Browse: 0 | Download: 0
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Received |
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2026-07-14 08:33 |
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Peer-Review Started |
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2026-07-14 08:33 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-05 07:53 |
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Revised |
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2026-08-15 08:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-09-09 01:23 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-22 10:01 |
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Articles in Press |
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2026-09-22 10:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-23 02:37 |
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Publish the Manuscript Online |
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2026-09-24 06:23 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Minireviews |
| Article Title |
Lung organoids for preclinical evaluation of stem cell therapies: Opportunities, evidence, and translational challenges
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lu-Yu Yang, Yuan-Fang Xing, Jia-Yi Chen, Zhi-Min Cao and Huan Ye |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Natural Science Foundation |
L234007 |
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| Corresponding Author |
Huan Ye, Full Professor, MD, Professor, Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No. 9 Beiguan Street, Tongzhou District, Beijing 101199, China. yehuan@bjxkyy.cn |
| Key Words |
Stem cell therapy; Lung organoids; Pulmonary fibrosis; Chronic obstructive pulmonary disease; Extracellular vesicles; Disease modeling |
| Core Tip |
Lung organoids are emerging human-relevant ex vivo models that may complement conventional preclinical systems in studying lung disease mechanisms and evaluating selected responses to stem cell-based therapeutic products. Current evidence does not support their use as clinically validated predictors of transplantation outcomes or as independent tools for comprehensive assessment of local safety-related responses. Standardized protocols and prospective studies linking organoid responses with animal and clinical outcomes are needed to establish their translational value. |
| Publish Date |
2026-09-24 06:23 |
| Citation |
Yang LY, Xing YF, Chen JY, Cao ZM, Ye H. Lung organoids for preclinical evaluation of stem cell therapies: Opportunities, evidence, and translational challenges. World J Stem Cells 2026; 18(9): 125409
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i9/125409.htm |
| DOI |
https://doi.org/10.4252/wjsc.125409 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
