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Articles Published Processes
11/10/2026 1:43:53 AM | Browse: 1 | Download: 0
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Received |
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2026-07-07 07:08 |
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Peer-Review Started |
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2026-07-07 07:08 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-06 01:31 |
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Revised |
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2026-08-16 06:01 |
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Publication Fee Transferred |
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2026-08-26 04:22 |
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Second Decision by Editor |
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2026-10-08 07:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 09:14 |
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Articles in Press |
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2026-10-08 09:14 |
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Edit the Manuscript by Language Editor |
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2026-10-15 21:17 |
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Typeset the Manuscript |
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2026-10-23 09:29 |
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Publish the Manuscript Online |
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2026-11-10 01:43 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Basic Study |
| Article Title |
Integrating Mendelian randomization and enzyme-linked immunosorbent assay validation identifies candidate mediators across the rheumatoid arthritis disease continuum
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuan-Song Song, Jun-Ling Luo, Xi-Fan Zheng, Ye-Ping Chen, Ze-Ming Li and Jun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi Traditional Chinese Medicine Appropriate Technology Development and Promotion Project |
No. GZSY22-62 |
| Guangxi Natural Science Foundation |
No. 2023GXNSFAA026402 |
| First Affiliated Hospital of Guangxi Medical University Innovation Team Cultivation Program |
No. YYZS2023004 |
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| Corresponding Author |
Jun Yao, Chief Physician, MD, Professor, Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. yaojun800524@126.com |
| Key Words |
Rheumatoid arthritis; Mendelian randomization; Inflammatory cytokines; CD40; C-C motif chemokine ligand 28; Matrix metalloproteinase-1; Interleukin-18 receptor 1; Enzyme-linked immunosorbent assay |
| Core Tip |
This study integrates Mendelian randomization with enzyme-linked immunosorbent assay validation to identify CD40, C-C motif chemokine ligand 28, and matrix metalloproteinase-1 as candidate mediators in rheumatoid arthritis, while interleukin-18 receptor 1 shows discordant Mendelian randomization (protective) and enzyme-linked immunosorbent assay (elevated) findings requiring mechanistic reconciliation. A hypothesised spatiotemporal cascade links CD40 to lymphoid immunity, C-C motif chemokine ligand 28 to synovitis, and matrix metalloproteinase-1 to cartilage degradation. Their positive intercorrelations suggest a potential synergistic loop, supporting further exploration of composite biomarker panels and combination strategies. Experimental validation demonstrates protein-level consistency rather than proof of causality, and all findings should be considered hypothesis generating. |
| Publish Date |
2026-11-10 01:43 |
| Citation |
Song YS, Luo JL, Zheng XF, Chen YP, Li ZM, Yao J. Integrating Mendelian randomization and enzyme-linked immunosorbent assay validation identifies candidate mediators across the rheumatoid arthritis disease continuum. World J Orthop 2026; 17(11): 125433
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| URL |
https://www.wjgnet.com/2218-5836/full/v17/i11/125433.htm |
| DOI |
https://doi.org/10.5312/wjo.125433 |
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