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Articles Published Processes
10/22/2026 2:34:08 AM | Browse: 0 | Download: 0
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Received |
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2026-07-09 06:13 |
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Peer-Review Started |
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2026-07-09 06:13 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-04 02:33 |
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Revised |
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2026-08-26 09:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-08 07:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 08:34 |
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Articles in Press |
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2026-10-08 08:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-15 01:04 |
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Publish the Manuscript Online |
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2026-10-22 02:34 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Oliver Mbuthia, Ishrat Mahjabeen, Mahmood Kayani, Azhar Mehmood, Jael Obiero, Takashi Matsumoto, Kefa Bosire and Marianne Mureithi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the United Nations Educational, Scientific and Cultural Organization - The World Academy of Sciences and COMSATS University Islamabad |
3240320712 |
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| Corresponding Author |
Oliver Mbuthia, PhD, Department of Medical Microbiology and Immunology, University of Nairobi, Kenyatta National Hospital, Nairobi P O Box 30197-00100, Nairobi City, Kenya. oliver.mbuthia@nairobi.msf.org |
| Key Words |
Helicobacter pylori; Gastric cancer; Virulence factors; Transcriptional profiling; Gene expression; Stage-associated transcriptional signature; Disease staging |
| Core Tip |
Standard diagnostic approaches for Helicobacter pylori generally establish whether the organism is present but do not resolve heterogeneity within gastric cancer. This study evaluates an expression-based discrimination model using a combined four-gene virulence transcript signature (cytotoxin-associated gene A, vacuolating cytotoxin A, blood group antigen-binding adhesin A, and induced by contact with epithelium gene A). The model identifies a stage-associated “adherence-to-invasion” transcriptional shift and, through a decision-tree classifier, discriminates early from advanced clinical stages with an area under the curve of 0.867, falling to 0.68 on nested cross-validation, a promising but modest signal warranting external validation. |
| Publish Date |
2026-10-22 02:34 |
| Citation |
Mbuthia O, Mahjabeen I, Kayani M, Mehmood A, Obiero J, Matsumoto T, Bosire K, Mureithi M. Helicobacter pylori virulence gene expression defines a stage-associated transcriptional signature in gastric cancer. World J Clin Oncol 2026; 17(10): 125453
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| URL |
https://www.wjgnet.com/2218-4333/full/v17/i10/125453.htm |
| DOI |
https://doi.org/10.5306/wjco.125453 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
