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Articles Published Processes
1/27/2015 3:33:00 PM | Browse: 1334 | Download: 923
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Received |
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2014-07-15 09:17 |
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Peer-Review Started |
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2014-07-15 19:58 |
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To Make the First Decision |
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2014-08-15 12:16 |
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Return for Revision |
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2014-08-20 13:16 |
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Revised |
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2014-09-01 17:43 |
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Second Decision |
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2014-09-30 10:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-09-30 10:36 |
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Articles in Press |
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2014-09-30 10:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-28 00:19 |
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Typeset the Manuscript |
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2015-01-16 16:59 |
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Publish the Manuscript Online |
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2015-01-27 15:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Autobiography |
| Article Title |
β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gui-Li Huang, Dong-Yan Shen, Cheng-Fu Cai, Qiu-Yan Zhang, Hong-Yue Ren and Qing-Xi Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81101502 |
| National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China |
J1310027 |
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| Corresponding Author |
Qing-Xi Chen, Professor, State Key Laboratory of Cellular Stress Biology, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, 42 Siming South Road, Xiamen 361005, Fujian Province, China. chenqxxm@126.com |
| Key Words |
β-escin; Multi-drug resistance; P-glycoprotein; GSK3β; Cholangiocarcinoma |
| Core Tip |
In our study, we received interesting and challenging results concerning the role of β-escin in reversing the multidrug resistance of cholangiocarcinoma (CCA). β-escin could enhance drug sensitivity of cholangiocarcinoma cells to common chemotherapeutics. 5-Fluorouracil, vincristine sulfate, or mitomycin C significantly reduced cell proliferation when combined with β-escin. In the molecular study, we found that β-escin could down-regulate P-gp expression via inhibiting the activation of GSK3β/β-catenin pathways. This study might offer a possible molecular basis for the further development of combinations of β-escin with common agents as a novel therapeutic approach for multidrug resistant CCA patients. |
| Publish Date |
2015-01-27 15:33 |
| Citation |
Huang GL, Shen DY, Cai CF, Zhang QY, Ren HY, Chen QX. β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma. World J Gastroenterol 2015; 21(4): 1148-1157 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i4/1148.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i4.1148 |
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