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Articles Published Processes
10/21/2026 2:09:36 AM | Browse: 1 | Download: 0
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Received |
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2026-07-08 08:44 |
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Peer-Review Started |
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2026-07-08 08:45 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-07 01:57 |
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Revised |
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2026-08-09 16:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-09-18 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-18 10:43 |
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Articles in Press |
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2026-09-18 10:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-12 00:14 |
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Publish the Manuscript Online |
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2026-10-21 02:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Treatment response in pediatric metabolic dysfunction-associated steatotic liver disease: Noninvasive endpoints and body composition
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Toshifumi Yodoshi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Toshifumi Yodoshi, Assistant Professor, MD, PhD, Division of Gastroenterology, Hepatology, Pancreatology and Nutrition, University of Iowa Stead Family Children’s Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United States. toshifumi-yodoshi@uiowa.edu |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Pediatric; Treatment response; Alanine aminotransferase; Magnetic resonance imaging proton density fat fraction; Elastography; Body composition; Sarcopenic obesity; Bariatric surgery; Glucagon-like peptide-1 receptor agonist |
| Core Tip |
Treatment response in pediatric metabolic dysfunction-associated steatotic liver disease cannot currently be defined by a single biomarker. Alanine aminotransferase, liver fat, liver stiffness, histology, cardiometabolic health, growth, body composition, and patient-reported outcomes capture complementary domains and may change at different rates. Diagnostic or prognostic performance does not by itself establish longitudinal responsiveness. This review separates those measurement properties, qualifies adult-derived thresholds, and proposes a three-tier, treatment-aware framework that distinguishes hepatic improvement with preserved muscle and normal growth from weight loss alone. |
| Publish Date |
2026-10-21 02:09 |
| Citation |
Yodoshi T. Treatment response in pediatric metabolic dysfunction-associated steatotic liver disease: Noninvasive endpoints and body composition. World J Hepatol 2026; 18(10): 125487
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i10/125487.htm |
| DOI |
https://doi.org/10.4254/wjh.125487 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
