BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/23/2026 8:57:26 AM | Browse: 3 | Download: 8
 |
Received |
|
2026-07-08 08:44 |
|
Peer-Review Started |
|
2026-07-08 08:45 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-07-18 07:32 |
|
Revised |
|
2026-07-31 19:36 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-09-11 02:52 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-09-11 09:27 |
|
Articles in Press |
|
2026-09-11 09:27 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-09-16 00:28 |
|
Publish the Manuscript Online |
|
2026-09-23 08:57 |
| ISSN |
2218-4333 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Retrospective Study |
| Article Title |
Rethinking treatment for non-metastatic deficient mismatch repair colorectal and small bowel cancers
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Alba Manuel-Vazquez, Miguel Soria Tristán, David Ricardo Luján, Sara Gortázar de las Casas, Ainhoa Valle Rubio, José Luis Ramos Rodríguez and Javier García-Septiem |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Alba Manuel-Vazquez, MD, PhD, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Calle tajo s/n, Villaviciosa de Odon 28670, Madrid, Spain. alba_manuel_vazquez@hotmail.com |
| Key Words |
Colorectal cancer; Mismatch repair deficiency; Immune checkpoint inhibitors; Rectal cancer; Small bowel neoplasm; Pembrolizumab; Dostarlimab; Nivolumab; Lynch syndrome |
| Core Tip |
This real-world retrospective study describes eight patients with non-metastatic mismatch repair (MMR)-deficient colorectal and small bowel adenocarcinoma treated with immunotherapy in different clinical settings. Favorable responses were observed across all tumor subsites. Complete clinical responses enabled a watch-and-wait strategy in some patients with locally advanced rectal cancer. In colon cancer immunotherapy facilitated minimally invasive surgery with pathological complete responses in all operated patients. Delayed MMR testing postponed treatment initiation in some cases, highlighting the need for systematic upfront immunohistochemical assessment at diagnosis. These findings support the feasibility of implementing immunotherapy-based strategies in routine surgical oncology practice beyond clinical trial settings. |
| Publish Date |
2026-09-23 08:57 |
| Citation |
Manuel-Vazquez A, Soria Tristán M, Luján DR, Gortázar de las Casas S, Valle Rubio A, Ramos Rodríguez JL, García-Septiem J. Rethinking treatment for non-metastatic deficient mismatch repair colorectal and small bowel cancers. World J Clin Oncol 2026; 17(9): 125491
|
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i9/125491.htm |
| DOI |
https://doi.org/10.5306/wjco.125491 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
