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Articles Published Processes
3/16/2015 6:04:00 PM | Browse: 1222 | Download: 1274
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Received |
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2014-07-15 08:46 |
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Peer-Review Started |
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2014-07-15 19:54 |
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To Make the First Decision |
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2014-08-15 12:16 |
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Return for Revision |
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2014-08-20 13:15 |
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Revised |
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2014-09-03 00:50 |
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Second Decision |
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2014-09-30 10:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-09-30 10:36 |
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Articles in Press |
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2014-09-30 10:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-03-03 15:30 |
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Publish the Manuscript Online |
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2015-03-16 18:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jordi Camps and Jorge Joven |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Instituto de Salud Carlos III |
PI08/1381 |
| Instituto de Salud Carlos III |
PI11/00130 |
| Carlos III Health Institute, Madrid, Spain |
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| Fondo Europeo de Desarrollo Regional |
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| Corresponding Author |
Jorge Joven, MD, PhD, Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, c/ Sant Llorenç 21, 43201 Reus, Spain. jorge.joven@urv.cat |
| Key Words |
Biomarkers; Cytokines; Inflammation; Metabolism; Mitochondrial dysfunction; Metabolic profiling; Obesity; Oxidation; Risk factors |
| Core Tip |
Recently acquired knowledge on the role of oxidation, inflammation and mitochondrial dysfunction in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) suggests a crucial role in the search for biological markers and therapeutic targets to alleviate the progression of the disease. Classically associated with obesity, the pathogenesis of NAFLD is extremely complex and mostly unknown. Consequently, the correct clinical management and prevention has not been established yet. Despite disparate results in the literature, mainly due to the different methods to measure the oxidative stress, there is currently no doubt that oxidative stress plays a crucial role. Similarly, the infiltration of monocytes, mainly due to the action of chemokines, is a relevant factor. However, to uncover the actual molecular mechanisms has proven to be more difficult than expected. The role of both oxidation and inflammation could be considered defensive and/or causative but the combination of these and other mechanisms may improve the understanding of NAFLD as a manifestation of mitochondrial disease. J. Camps and J. Joven. Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: the search for alternative causative factors. |
| Publish Date |
2015-03-16 18:04 |
| Citation |
Camps J, Joven J. Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors. World J Gastroenterol 2015; 21(10): 2875-2882 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i10/2875.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i10.2875 |
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