Publication Name	World Journal of Stem Cells
Manuscript ID	12552
Country	Bulgaria

Received	2014-07-15 08:45
Peer-Review Started	2014-07-15 16:13
To Make the First Decision	2014-08-14 14:25
Return for Revision	2014-08-16 20:55
Revised	2014-08-20 14:26
Second Decision	2014-09-10 09:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-10 09:25
Articles in Press	2014-09-10 09:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-09-17 16:19
Typeset the Manuscript	2014-09-22 17:35
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	Secretion of immunoregulatory cytokines by mesenchymal stem cells
Manuscript Source	Invited Manuscript
All Author List	Dobroslav Kyurkchiev, Ivan Bochev, Ekaterina Ivanova-Todorova, Milena Mourdjeva, Tsvetelina Oreshkova, Kalina Belemezova and Stanimir Kyurkchiev
Funding Agency and Grant Number
Corresponding Author	Dobroslav Kyurkchiev, MD, PhD, Associate Professor, University Hospital “St. Ivan Rilski, Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, 15 “Acad. Ivan Geshov” Str., Sofia 1431, Bulgaria. dsk666@gmail.com
Key Words	Mesenchymal stem cells; Immunomodulation; Cytokines; Chemokines; Dendritic cells
Core Tip	The autoimmune diseases affect approximately 5% of human population leading to serious disability of the patients and effective methods to treat these diseases are not perfect, still. The mesenchymal stem cells (MSCs) are assumed to be promising agents both for regenerative medicine and cell therapy of autoimmune disorders. Under the influence of some factors the mesenchymal stem cells secrete cytokines which as a whole induce suppression of the immune response. Studies on the secreted cytokines and the precise mechanisms involved in these suppressive mechanisms would create possibilities for efficient application of the MSCs as therapeutic means for treatment of autoimmune diseases.
Publish Date	2014-09-28 14:56
Citation	Kyurkchiev D, Bochev I, Ivanova-Todorova E, Mourdjeva M, Oreshkova T, Belemezova K, Kyurkchiev S. Secretion of immunoregulatory cytokines by mesenchymal stem cells. World J Stem Cells 2014; 6(5): 552-570
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/552.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.552

Full Article (PDF)	WJSC-6-552.pdf
Full Article (Word)	WJSC-6-552.doc
Manuscript File	12552-Review.doc
Answering Reviewers	12552-Answering reviewers.pdf
Copyright License Agreement	12552-Copyright assignment.pdf
Peer-review Report	12552-Peer review(s).pdf
Scientific Misconduct Check	12552-CrossCheck.jpg
Scientific Editor Work List	12552-Scientific editor work list.pdf