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Publication Name World Journal of Stem Cells
Manuscript ID 125599
Country China
Received
2026-07-14 09:01
Peer-Review Started
2026-07-14 09:02
First Decision by Editorial Office Director
Return for Revision
2026-08-10 01:44
Revised
2026-08-12 13:21
Publication Fee Transferred
Second Decision by Editor
2026-09-10 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-11 09:28
Articles in Press
2026-09-11 09:28
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-09-15 09:09
Publish the Manuscript Online
2026-09-24 06:23
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title RNA-centered mechanisms sustaining self-renewal in hepatocellular carcinoma stem cells: Effector dosage, protein output and regulatory deployment
Manuscript Source Invited Manuscript
All Author List Yi Deng and Long Yan
ORCID
Author(s) ORCID Number
Yi Deng http://orcid.org/0000-0002-7110-1883
Long Yan http://orcid.org/0009-0001-3605-3943
Funding Agency and Grant Number
Corresponding Author Yi Deng, MD, Department of Oncology, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. dengyi@csu.edu.cn
Key Words Hepatocellular carcinoma; Cancer stem cells; RNA-centered regulation; Self-renewal; Post-transcriptional control
Core Tip Here, we examine how RNA molecules and RNA-processing machineries maintain functional self-renewal by controlling self-renewal effectors. Rather than cataloging RNA classes, we organize the evidence by molecular operation. RNA mechanisms first tune effector dosage and availability through transcript repression, stabilization, export, translational access and protein turnover.
Publish Date 2026-09-24 06:23
Citation

Deng Y, Yan L. RNA-centered mechanisms sustaining self-renewal in hepatocellular carcinoma stem cells: Effector dosage, protein output and regulatory deployment. World J Stem Cells 2026; 18(9): 125599

URL https://www.wjgnet.com/1948-0210/full/v18/i9/125599.htm
DOI https://doi.org/10.4252/wjsc.125599
Full Article (PDF) WJSC-18-125599-with-cover.pdf
Manuscript File 125599_Auto_Edited_031457.docx
Answering Reviewers 125599-answering-reviewers.pdf
Audio Core Tip 125599-audio.mp3
Conflict-of-Interest Disclosure Form 125599-conflict-of-interest-statement.pdf
Copyright License Agreement 125599-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 125599-non-native-speakers.pdf
Peer-review Report 125599-peer-reviews.pdf
Scientific Misconduct Check 125599-scientific-misconduct-check.png
CrossCheck Report 125599-crosscheck-report.pdf