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Articles Published Processes
10/26/2026 6:39:38 AM | Browse: 0 | Download: 0
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Received |
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2026-07-15 08:49 |
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Peer-Review Started |
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2026-07-15 08:49 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-04 03:07 |
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Revised |
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2026-09-07 20:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-13 05:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-20 09:35 |
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Articles in Press |
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2026-10-20 09:35 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-21 01:51 |
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Publish the Manuscript Online |
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2026-10-26 06:39 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Soluble immunosuppressive checkpointome of mesenchymal stromal cells: Immunoregulatory mechanisms and a conceptual framework for potency assessment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdullah Salim Al-Karawi and Ali Saad Al-Budairi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdullah Salim Al-Karawi, Researcher, Department of Microbiology, College of Science, Mustansiriyah University, Baghdad 0011, Iraq. abdullah.s.shaker@uomustansiriyah.edu.iq |
| Key Words |
Mesenchymal stromal cells; Soluble immune checkpoints; Programmed death ligand 1; Galectin-9; Human leukocyte antigen-G5; Potency assay; Cell therapy; Immunomodulation |
| Core Tip |
Mesenchymal stromal cells release a defined set of soluble immune checkpoint proteins, notably soluble programmed death ligand 1 and 2, galectin-9, galectin-1 and the secreted human leukocyte antigen-G5 isoform. Treated separately until now, they form a single inducible module we term the soluble checkpointome. Because its abundance rises with inflammatory licensing and tracks with suppressive capacity, it offers a licensed, cell-free, multi-analyte panel well suited to the potency assays regulators require, and amenable to composite scoring supported by machine learning. |
| Publish Date |
2026-10-26 06:39 |
| Citation |
Al-Karawi AS, Al-Budairi AS. Soluble immunosuppressive checkpointome of mesenchymal stromal cells: Immunoregulatory mechanisms and a conceptual framework for potency assessment. World J Stem Cells 2026; 18(10): 125673
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i10/125673.htm |
| DOI |
https://doi.org/10.4252/wjsc.125673 |
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