| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Minireviews |
| Article Title |
Regenerative-system dysfunction in organ fibrosis: Maladaptive regeneration, fibrotic memory, and therapeutic reprogramming
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Peng Li, Xin-Yao Chen, Qing Wang, Yu-Yang Du, Ting-Ting Guo, Jia-Ni Lin, Jia-Yue Fu, Ming-Li Xie, Jia-Hui Liu, Jian-Lu Gao, Ming-Ming Wang and Sai Luo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Heilongjiang Provincial Natural Science Foundation |
PL2025H085, QC2018102 |
| National Natural Science Foundation of China |
82102356 |
| Outstanding Young Medical Talents Training Funding Project of the First Affiliated Hospital of Harbin Medical University |
2021J05 |
| Scientific Research Innovation Fund of the First Affiliated Hospital of Harbin Medical University |
2019B24 |
| Heilongjiang Provincial Natural Science Foundation |
PL2024H066 |
| Fundamental Research Funds for Provincial Universities in Heilongjiang Province |
2025-KYYWF-ZR0190 |
| Fundamental Research Funds for Provincial Universities in Heilongjiang Province |
2025-KYYWF-ZR0177 |
| Heilongjiang Provincial Natural Science Foundation |
BS2025H007 |
| “New Era Heilongjiang Province Excellent Master’s and Doctoral Dissertation” Funding Project |
LJYXL2022-079 |
| Undergraduate Innovation and Entrepreneurship Training Program of Heilongjiang Province |
S202310226027 |
| Undergraduate Innovation and Entrepreneurship Training Program of Harbin Medical University |
202310226027 |
| Harbin Medical University Youth Science Foundation |
2023-KYYWF-0142 |
| Graduate Research and Practice Innovation Project of Harbin Medical University |
YJSCX2023-206HYD |
|
| Corresponding Author |
Sai Luo, Full Professor, Department of Plastic and Cosmetic Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. 101301@hrbmu.edu.cn |
| Key Words |
Fibrosis; Regeneration; Stem cells; Cellular senescence; Epigenesis; Genetic; Extracellular matrix; Cellular reprogramming; Fibrotic memory |
| Core Tip |
Fibrosis can involve failed tissue regeneration as well as scar accumulation. This review compares organ-specific evidence for maladaptive repair and fibrotic memory without treating all repair-associated cells as stem cells. Direct memory evidence is separated from persistent abnormalities during ongoing disease. Therapeutic reprogramming requires controlled, durable cellular-state or lineage correction; extracellular matrix normalization, immune and metabolic modulation, cell replacement, and organoid-guided screening remain distinct. The proposed framework prioritizes testable mechanisms, context-dependent reversibility, and safety rather than assuming that preclinical state changes restore human tissue function. |
| Publish Date |
2026-10-26 06:39 |
| Citation |
Li JP, Chen XY, Wang Q, Du YY, Guo TT, Lin JN, Fu JY, Xie ML, Liu JH, Gao JL, Wang MM, Luo S. Regenerative-system dysfunction in organ fibrosis: Maladaptive regeneration, fibrotic memory, and therapeutic reprogramming. World J Stem Cells 2026; 18(10): 125689
|
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i10/125689.htm |
| DOI |
https://doi.org/10.4252/wjsc.125689 |
