BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
1/20/2015 9:10:00 PM | Browse: 1344 | Download: 1923
 |
Received |
|
2014-07-16 09:21 |
|
Peer-Review Started |
|
2014-07-16 18:58 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2014-08-18 17:15 |
|
Revised |
|
2014-08-22 19:14 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2014-10-15 07:33 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2014-10-15 07:48 |
|
Articles in Press |
|
2014-10-15 08:22 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2015-01-12 21:57 |
|
Publish the Manuscript Online |
|
2015-01-20 20:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-Clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Valentin Becker, Romina Drabner, Simone Graf, Christoph Schlag, Simon Nennstiel, Anna Maria Buchberger, Roland M Schmid, Dieter Saur and Monther Bajbouj |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dr. Valentin Becker, II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 22 Ismaninger str., 81675 München, Germany. valentin.becker@lrz.tum.de |
| Key Words |
Laryngopharyngeal reflux; Proton pump inhibitor; Gastroesophageal reflux disease; Pathomechanism |
| Core Tip |
The pathophysiology and objective diagnosis of laryngopharyngeal reflux (LPR) is still unclear. The response to standard therapy (proton pump inhibitors) is poor. Laryngeal proton pumps (H+K+-ATPase) are often considered to be potential causes of LPR. The clinical significance of laryngeal proton pumps (H+K+-ATPase) is unclear. We present the first prospective series evaluating the laryngeal H+K+-ATPase, pharyngeal pH and symptom scores in patients with LPR symptoms. Laryngeal H+K+-ATPases can only be sporadically detected, and they are unlikely to cause LPR symptoms. The role of pharyngeal pH-metry remains unclear and its use can only be recommended for patients in the research study setting.
|
| Publish Date |
2015-01-20 20:12 |
| Citation |
Becker V, Drabner R, Graf S, Schlag C, Nennstiel S, Buchberger AM, Schmid RM, Saur D, Bajbouj M. New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease. World J Gastroenterol 2015; 21(3): 982-987 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i3/982.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i3.982 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
