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Articles Published Processes
1/20/2015 9:10:00 PM | Browse: 1124 | Download: 1458
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Received |
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2014-07-16 09:21 |
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Peer-Review Started |
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2014-07-16 18:58 |
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To Make the First Decision |
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2014-08-15 12:16 |
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Return for Revision |
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2014-08-18 17:15 |
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Revised |
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2014-08-22 19:14 |
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Second Decision |
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2014-10-15 07:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-15 07:48 |
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Articles in Press |
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2014-10-15 08:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-12 21:57 |
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Publish the Manuscript Online |
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2015-01-20 20:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-Clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Valentin Becker, Romina Drabner, Simone Graf, Christoph Schlag, Simon Nennstiel, Anna Maria Buchberger, Roland M Schmid, Dieter Saur and Monther Bajbouj |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Valentin Becker, II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 22 Ismaninger str., 81675 München, Germany. valentin.becker@lrz.tum.de |
| Key Words |
Laryngopharyngeal reflux; Proton pump inhibitor; Gastroesophageal reflux disease; Pathomechanism |
| Core Tip |
The pathophysiology and objective diagnosis of laryngopharyngeal reflux (LPR) is still unclear. The response to standard therapy (proton pump inhibitors) is poor. Laryngeal proton pumps (H+K+-ATPase) are often considered to be potential causes of LPR. The clinical significance of laryngeal proton pumps (H+K+-ATPase) is unclear. We present the first prospective series evaluating the laryngeal H+K+-ATPase, pharyngeal pH and symptom scores in patients with LPR symptoms. Laryngeal H+K+-ATPases can only be sporadically detected, and they are unlikely to cause LPR symptoms. The role of pharyngeal pH-metry remains unclear and its use can only be recommended for patients in the research study setting.
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| Publish Date |
2015-01-20 20:12 |
| Citation |
Becker V, Drabner R, Graf S, Schlag C, Nennstiel S, Buchberger AM, Schmid RM, Saur D, Bajbouj M. New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease. World J Gastroenterol 2015; 21(3): 982-987 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i3/982.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i3.982 |
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