Publication Name	World Journal of Stem Cells
Manuscript ID	12573
Country	Germany

Received	2014-07-17 09:27
Peer-Review Started	2014-07-17 11:39
To Make the First Decision	2014-08-14 14:24
Return for Revision	2014-08-16 20:35
Revised	2014-08-19 20:22
Second Decision	2014-12-11 17:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-17 16:24
Articles in Press	2014-12-17 16:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-07 08:45
Publish the Manuscript Online	2015-03-20 10:47

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Review
Article Title	Induced pluripotent stem cells: Mechanisms, achievements and perspectives in farm animals
Manuscript Source	Invited Manuscript
All Author List	Dharmendra Kumar, Thirumala R Talluri, Taruna Anand and Wilfried A Kues
Funding Agency and Grant Number	Funding Agency Grant Number CREST fellowship from Department of Biotechnology, Ministry of Science and Technology, Government of India (DK) International fellowship for PhD from ICAR (TRT), Government of India International training in generation of iPS cells from NAIP, ICAR, Government of India (TA)
Corresponding Author	Dr. Wilfried A Kues, PhD, Institute of Farm Animal Genetics, Friedrich-Loeffler-Institute, Höltystr. 10, 31535 Mariensee, Germany. wilfried.kues@fli.bund.de
Key Words	Reprogramming; Large animal models; Stemness; Chimera; Germline transmission; Induced pluripotent stem cells; Gene delivery
Core Tip	The generation of an induced status of pluripotency in somatic cells by ectopic expression of core transcription factors allows to extending advanced genetic modifications and reproductive techniques to species, for which the derivation of genuine embryonic stem cells was not successful till now. The commonly employed viral gene transfer may be genotoxic and therefore non-viral methods for iPS cell derivation are intensively studied. In this review, we focus on the mechanisms of cellular reprogramming and current methods used to induce pluripotency.
Publish Date	2015-03-20 10:47
Citation	Kumar D, Talluri TR, Anand T, Kues WA. Induced pluripotent stem cells: Mechanisms, achievements and perspectives in farm animals. World J Stem Cells 2015; 7(2): 315-328
URL	http://www.wjgnet.com/1948-0210/full/v7/i2/315.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i2.315

Full Article (PDF)	WJSC-7-315.pdf
Full Article (Word)	WJSC-7-315.doc
Manuscript File	12573-Review.doc
Answering Reviewers	12573-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12573-Conflict-of-interest statement.pdf
Copyright License Agreement	12573-Copyright assignment.pdf
Peer-review Report	12573-Peer review(s).pdf
Scientific Misconduct Check	12573-CrossCheck.jpg
Scientific Editor Work List	12573-Scientific editor work list.pdf