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Articles Published Processes
2/13/2015 9:30:00 AM | Browse: 1434 | Download: 1624
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Received |
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2014-07-16 08:54 |
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Peer-Review Started |
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2014-07-16 13:57 |
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To Make the First Decision |
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2014-08-28 14:50 |
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Return for Revision |
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2014-09-02 10:20 |
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Revised |
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2014-09-30 20:02 |
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Second Decision |
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2014-11-06 12:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-19 11:12 |
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Articles in Press |
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2014-11-19 11:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-27 16:20 |
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Publish the Manuscript Online |
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2015-02-13 09:30 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Targeting the tumor stroma in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Femke Heindryckx and Pär Gerwins |
| Funding Agency and Grant Number |
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| Corresponding Author |
Femke Heindryckx, PhD, Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, PO Box 582, SE-75123 Uppsala,
Sweden. femke.heindryckx@mcb.uu.se
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| Key Words |
Hepatocellular carcinoma; Stellate cells; Cirrhosis; Angiogenesis; Macrophages; Inflammation |
| Core Tip |
Hepatocellular carcinoma is a primary liver tumor that usually develops in a background of chronic liver disease and fibrosis. It is the underlying chronic inflammation that creates an environment that not only causes but also enhances the formation and growth of tumors. The stromal compartment-including hepatic stellate cells, macrophages and endothelial cells-actively contribute to tumorigenesis, while the tumor itself influences these cells to create a background that is beneficial for tumor growth. This review focuses on the interplay between stroma and tumor cells, as well as therapeutic strategies that aim to target these complex interactions. |
| Publish Date |
2015-02-13 09:30 |
| Citation |
Heindryckx F, Gerwins P. Targeting the tumor stroma in hepatocellular carcinoma. World J Hepatol 2015; 7(2): 165-176 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i2/165.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i2.165 |
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