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Publication Name World Journal of Experimental Medicine
Manuscript ID 126036
Country Italy
Received
2026-07-29 03:36
Peer-Review Started
2026-08-05 02:34
First Decision by Editorial Office Director
Return for Revision
2026-09-08 07:59
Revised
2026-09-11 12:14
Publication Fee Transferred
Second Decision by Editor
2026-09-17 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-17 09:20
Articles in Press
2026-09-17 09:20
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-09-18 03:51
Publish the Manuscript Online
2026-09-20 03:29
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Ophthalmology
Manuscript Type Minireviews
Article Title Corneal nerve imaging in systemic neuropathy: A minireview of experimental and precision medicine applications
Manuscript Source Invited Manuscript
All Author List Matteo Capobianco, Francesco Cappellani, Ehimare Enaholo and Marco Zeppieri
ORCID
Author(s) ORCID Number
Ehimare Enaholo http://orcid.org/0000-0002-2410-7510
Marco Zeppieri http://orcid.org/0000-0003-0999-5545
Funding Agency and Grant Number
Corresponding Author Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words Peripheral neuropathy; Corneal nerves; Small fiber neuropathy; Confocal microscopy; Precision medicine
Core Tip Corneal confocal microscopy provides a fast, non-invasive quantitative assessment of corneal small-nerve morphology and has shown reproducible group-level abnormality in diabetic peripheral neuropathy and a few other systemic neuropathies. Nevertheless, population-based distinctions do not mean a reliable diagnosis in a single patient. Research shows that when it comes to diabetic neuropathy, the best studied condition, the variability in diagnostic performance can be attributed to the studied population, the reference standard employed, the sampling protocol used, the analysis chosen and the threshold selected. Also, there is considerable overlap and variation between those affected and not affected.
Publish Date 2026-09-20 03:29
Citation

Capobianco M, Cappellani F, Enaholo E, Zeppieri M. Corneal nerve imaging in systemic neuropathy: A minireview of experimental and precision medicine applications. World J Exp Med 2026; 16(3): 126036

URL https://www.wjgnet.com/2220-315x/full/v16/i3/126036.htm
DOI https://doi.org/10.5493/wjem.126036
Full Article (PDF) WJEM-16-126036-with-cover.pdf
Manuscript File 126036_Auto_Edited_081533.docx
Answering Reviewers 126036-answering-reviewers.pdf
Audio Core Tip 126036-audio.m4a
Conflict-of-Interest Disclosure Form 126036-conflict-of-interest-statement.pdf
Copyright License Agreement 126036-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 126036-non-native-speakers.pdf
Peer-review Report 126036-peer-reviews.pdf
Scientific Misconduct Check 126036-scientific-misconduct-check.png
CrossCheck Report 126036-crosscheck-report.pdf