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Articles Published Processes
10/22/2026 2:34:09 AM | Browse: 0 | Download: 0
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Received |
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2026-07-28 02:28 |
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Peer-Review Started |
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2026-08-07 08:49 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-18 08:00 |
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Revised |
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2026-08-31 10:47 |
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Publication Fee Transferred |
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2026-09-15 10:05 |
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Second Decision by Editor |
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2026-10-13 06:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-13 09:55 |
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Articles in Press |
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2026-10-13 09:55 |
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Edit the Manuscript by Language Editor |
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2026-10-14 11:50 |
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Typeset the Manuscript |
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2026-10-16 09:25 |
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Publish the Manuscript Online |
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2026-10-22 02:34 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Translational Research |
| Article Title |
Integrated single-cell transcriptomic analysis of brain and lymph node metastases in non small cell lung cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhang-Nan Liu, Miao-Miao Li, Yu Ping, Qi-Tai Zhao, Li-Ping Wang and Yi Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yi Zhang, Chief Physician, Full Professor, MD, PhD, Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. yizhang@zzu.edu.cn |
| Key Words |
Non small cell lung cancer; scRNA-seq; T cells; Macrophages; unfolded protein response; Brain metastasis; Lymph node metastasis |
| Core Tip |
Our study offers a panoramic analysis of two distinct metastatic sites within the same disease context. Our main findings are: The distribution of tumor epithelial subpopulations differs across metastatic foci; Abnormal activation of unfolded protein response (UPR) occurs in both metastatic sites; and a dual immunosuppressive microenvironment is characterized. Multivariate Cox regression analysis based on The Cancer Genome Atlas data revealed that, among the tumor epithelial subpopulations, the C14_PBK_Tumor subtype was associated with worse prognosis in lung adenocarcinoma patients. Importantly, multiplex immunohistochemistry was performed to assess macrophage infiltration and the expression of UPR-related proteins. These findings still require further verification through functional experiments and prospective studies. |
| Publish Date |
2026-10-22 02:34 |
| Citation |
Liu ZN, Li MM, Ping Y, Zhao QT, Wang LP, Zhang Y. Integrated single-cell transcriptomic analysis of brain and lymph node metastases in non small cell lung cancer. World J Clin Oncol 2026; 17(10): 126162
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| URL |
https://www.wjgnet.com/2218-4333/full/v17/i10/126162.htm |
| DOI |
https://doi.org/10.5306/wjco.126162 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
