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Articles Published Processes
3/16/2015 6:04:00 PM | Browse: 1233 | Download: 1703
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Received |
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2014-07-17 20:30 |
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Peer-Review Started |
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2014-07-18 10:03 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-08-15 17:30 |
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Revised |
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2014-08-29 17:43 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-10-21 17:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-10-21 17:53 |
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Articles in Press |
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2014-10-21 18:09 |
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Edit the Manuscript by Language Editor |
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2014-12-16 05:04 |
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Typeset the Manuscript |
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2015-03-02 10:20 |
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Publish the Manuscript Online |
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2015-03-16 18:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Autobiography |
| Article Title |
Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Gong, Jun Ren, Kun Liu and Li-Ming Tang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Nanjing Medical University institutional grant |
11ZLKF06 (to SYC and LMT) |
| Changzhou basic research program of science and technology |
CJ20122014 |
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| Corresponding Author |
Li-Ming Tang, MD, PhD, Department of Gastrointestinal Surgery, Nanjing Medical University Affiliated Changzhou No. 2 People’s Hospital, No. 188 Gehu Road, Changzhou 213000, Jiangsu Province, China. drtanglm@njmu.edu.cn |
| Key Words |
Gastric cancer; miR-133a; Tumor suppressor; Insulin-like growth factor 1 receptor |
| Core Tip |
miRNA (miR)-133a is a tumor suppressor in several cancers. It was recently shown that miR-133a inhibits proliferation, migration and invasion in gastric cancer (GC) by targeting transcription factor Sp1. Here, we further investigated the biological role of miR-133a in apoptosis and xenograft tumorigenesis, and its relationship with clinicopathological parameters. miR-133a downregulation was associated with degree of differentiation, local invasion and TNM stage, whereas forced miR-133a expression inhibited cell proliferation, migration and invasion, and xenograft tumorigenesis, and induced apoptosis. Furthermore, insulin-like growth factor 1 receptor was found to be another target gene of miR-133a in GC. |
| Publish Date |
2015-03-16 18:04 |
| Citation |
Gong Y, Ren J, Liu K, Tang LM. Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. World J Gastroenterol 2015; 21(10): 2949-2958 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i10/2949.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i10.2949 |
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