Publication Name	World Journal of Gastroenterology
Manuscript ID	12621
Country	China

Received	2014-07-17 20:30
Peer-Review Started	2014-07-18 10:03
To Make the First Decision	2014-08-06 17:25
Return for Revision	2014-08-15 17:30
Revised	2014-08-29 17:43
Second Decision	2014-10-21 17:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-21 17:53
Articles in Press	2014-10-21 18:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-12-16 05:04
Typeset the Manuscript	2015-03-02 10:20
Publish the Manuscript Online	2015-03-16 18:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Autobiography
Article Title	Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Gong, Jun Ren, Kun Liu and Li-Ming Tang
Funding Agency and Grant Number	Funding Agency Grant Number Nanjing Medical University institutional grant 11ZLKF06 (to SYC and LMT) Changzhou basic research program of science and technology CJ20122014
Corresponding Author	Li-Ming Tang, MD, PhD, Department of Gastrointestinal Surgery, Nanjing Medical University Affiliated Changzhou No. 2 People’s Hospital, No. 188 Gehu Road, Changzhou 213000, Jiangsu Province, China. drtanglm@njmu.edu.cn
Key Words	Gastric cancer; miR-133a; Tumor suppressor; Insulin-like growth factor 1 receptor
Core Tip	miRNA (miR)-133a is a tumor suppressor in several cancers. It was recently shown that miR-133a inhibits proliferation, migration and invasion in gastric cancer (GC) by targeting transcription factor Sp1. Here, we further investigated the biological role of miR-133a in apoptosis and xenograft tumorigenesis, and its relationship with clinicopathological parameters. miR-133a downregulation was associated with degree of differentiation, local invasion and TNM stage, whereas forced miR-133a expression inhibited cell proliferation, migration and invasion, and xenograft tumorigenesis, and induced apoptosis. Furthermore, insulin-like growth factor 1 receptor was found to be another target gene of miR-133a in GC.
Publish Date	2015-03-16 18:04
Citation	Gong Y, Ren J, Liu K, Tang LM. Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. World J Gastroenterol 2015; 21(10): 2949-2958
URL	http://www.wjgnet.com/1007-9327/full/v21/i10/2949.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i10.2949

Full Article (PDF)	WJG-21-2949.pdf
Full Article (Word)	WJG-21-2949.doc
Manuscript File	12621-Review.doc
Answering Reviewers	12621-Answering reviewers.pdf
Copyright License Agreement	12621-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12621-Language certificate.pdf
Peer-review Report	12621-Peer review(s).pdf
Scientific Misconduct Check	12621-CrossCheck.jpg
Scientific Editor Work List	12621-Scientific editor work list.pdf