Publication Name	World Journal of Stem Cells
Manuscript ID	12623
Country	Taiwan

Received	2014-07-17 20:33
Peer-Review Started	2014-07-18 10:46
To Make the First Decision	2014-08-28 14:47
Return for Revision	2014-09-02 15:33
Revised	2014-09-12 18:31
Second Decision	2014-12-11 17:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-17 16:25
Articles in Press	2014-12-17 16:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-06 16:07
Publish the Manuscript Online	2015-03-20 10:47

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways
Manuscript Source	Invited Manuscript
All Author List	Jen-Hua Chuang, Li-Chu Tung and Yenshou Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council NSC101-2311-B-003-005 National Science Council NSC102-2311-B-003-003 National Taiwan Normal University 103T3040B06 National Taiwan Normal University 103T3040C06 National Taiwan Normal University 104T3040C06
Corresponding Author	Dr. Yenshou Lin, Associate Professor, Department of Life Science, National Taiwan Normal University, 88, Ting-Chou Road, Section 4, Taipei 116, Taiwan. yenshoulin@ntnu.edu.tw
Key Words	Neurons; Differentiation; Embryonic stem cells; Signaling; Pathways
Core Tip	Neurons are derived from embryonic stem cells (ESCs) and have been a focus of research recently, particularly because of their application in regenerative medicine. Here we review and summarize the signaling pathways that have been reported to be involved in neuronal differentiation of ESCs, mainly in vitro. The inducers and pathways explored include retinoic acid, Wnt/β-catenin, transforming growth factor/bone morphogenetic protein, Notch, fibroblast growth factor, cytokine, Hedgehog, c-Jun N-terminal kinase/mitogen-activated protein kinase and others. Some miscellaneous factors are also explored. Elucidating these signals in detail should make a significant contribution to future progress in stem cell biology and should also accelerate the application of stem cells in translational medicine.
Publish Date	2015-03-20 10:47
Citation	Chuang JH, Tung LC, Lin Y. Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways. World J Stem Cells 2015; 7(2): 437-447
URL	http://www.wjgnet.com/1948-0210/full/v7/i2/437.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i2.437

Full Article (PDF)	WJSC-7-437.pdf
Full Article (Word)	WJSC-7-437.doc
Manuscript File	12623-Review.docx
Answering Reviewers	12623-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12623-Conflict-of-interest statement.pdf
Copyright License Agreement	12623-Copyright assignment.pdf
Peer-review Report	12623-Peer review(s).pdf
Scientific Misconduct Check	12623-CrossCheck.jpg
Scientific Editor Work List	12623-Scientific editor work list.pdf