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3/20/2015 10:48:00 AM | Browse: 996 | Download: 1325
Publication Name World Journal of Stem Cells
Manuscript ID 12623
Country/Territory Taiwan
Received
2014-07-17 20:33
Peer-Review Started
2014-07-18 10:46
To Make the First Decision
2014-08-28 14:47
Return for Revision
2014-09-02 15:33
Revised
2014-09-12 18:31
Second Decision
2014-12-11 17:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-12-17 16:25
Articles in Press
2014-12-17 16:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-02-06 16:07
Publish the Manuscript Online
2015-03-20 10:47
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways
Manuscript Source Invited Manuscript
All Author List Jen-Hua Chuang, Li-Chu Tung and Yenshou Lin
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Council NSC101-2311-B-003-005
National Science Council NSC102-2311-B-003-003
National Taiwan Normal University 103T3040B06
National Taiwan Normal University 103T3040C06
National Taiwan Normal University 104T3040C06
Corresponding Author Dr. Yenshou Lin, Associate Professor, Department of Life Science, National Taiwan Normal University, 88, Ting-Chou Road, Section 4, Taipei 116, Taiwan. yenshoulin@ntnu.edu.tw
Key Words Neurons; Differentiation; Embryonic stem cells; Signaling; Pathways
Core Tip Neurons are derived from embryonic stem cells (ESCs) and have been a focus of research recently, particularly because of their application in regenerative medicine. Here we review and summarize the signaling pathways that have been reported to be involved in neuronal differentiation of ESCs, mainly in vitro. The inducers and pathways explored include retinoic acid, Wnt/β-catenin, transforming growth factor/bone morphogenetic protein, Notch, fibroblast growth factor, cytokine, Hedgehog, c-Jun N-terminal kinase/mitogen-activated protein kinase and others. Some miscellaneous factors are also explored. Elucidating these signals in detail should make a significant contribution to future progress in stem cell biology and should also accelerate the application of stem cells in translational medicine.
Publish Date 2015-03-20 10:47
Citation Chuang JH, Tung LC, Lin Y. Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways. World J Stem Cells 2015; 7(2): 437-447
URL http://www.wjgnet.com/1948-0210/full/v7/i2/437.htm
DOI http://dx.doi.org/10.4252/wjsc.v7.i2.437
Full Article (PDF) WJSC-7-437.pdf
Full Article (Word) WJSC-7-437.doc
Manuscript File 12623-Review.docx
Answering Reviewers 12623-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 12623-Conflict-of-interest statement.pdf
Copyright License Agreement 12623-Copyright assignment.pdf
Peer-review Report 12623-Peer review(s).pdf
Scientific Misconduct Check 12623-CrossCheck.jpg
Scientific Editor Work List 12623-Scientific editor work list.pdf