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Articles Published Processes
3/9/2015 3:58:00 PM | Browse: 1011 | Download: 1050
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Received |
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2014-07-18 08:28 |
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Peer-Review Started |
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2014-07-18 09:22 |
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To Make the First Decision |
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2014-09-15 16:19 |
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Return for Revision |
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2014-09-19 17:41 |
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Revised |
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2014-10-16 01:45 |
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Second Decision |
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2014-11-11 10:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-11-11 10:26 |
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Articles in Press |
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2014-11-11 11:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-02-25 16:53 |
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Publish the Manuscript Online |
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2015-03-09 15:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Observational Study |
| Article Title |
CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dennis R Johnson, Maisoun Abdelbaqui, Maryam Tahmasbi, Zoltan Mayer, Hung-Wei Lee, Mokenge P Malafa and Domenico Coppola |
| Funding Agency and Grant Number |
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| Corresponding Author |
Domenico Coppola, MD, Department of Anatomic Pathology, Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., MCC-PATH, Tampa, FL 33612, United States. domenico.coppola@moffitt.org |
| Key Words |
Barrett’s esophagus; Alcian blue pH 2.5; CDX2; Intestinal metaplasia; Esophageal glands; Columnar blue cell |
| Core Tip |
Our data show that the use of CDX2 immunostain in biopsies performed to rule out esophageal intestinal metaplasia (Barrett esophagus) has the advantage of discriminating between Barrett’s esophagus and esophageal glands. The latter is typically strongly positive for alcian blue (AB) pH 2.5 but negative for CDX2. CDX2 also discriminates between BE and columnar blue cells which are also positive for AB. Our data shows that CDX2 has a better positive predictive value in detecting intestinal metaplasia as compared to AB (95.6% vs 71.5% respectively). These results support the utility of CDX2 stain in the correct diagnosis of Barrett esophagus. |
| Publish Date |
2015-03-09 15:58 |
| Citation |
Johnson DR, Abdelbaqui M, Tahmasbi M, Mayer Z, Lee HW, Malafa MP, Coppola D. CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia. World J Gastroenterol 2015; 21(9): 2770-2776 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i9/2770.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i9.2770 |
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