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Articles Published Processes
12/10/2015 10:35:00 AM | Browse: 1273 | Download: 1592
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Received |
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2014-07-19 12:14 |
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Peer-Review Started |
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2014-07-20 09:55 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-08-20 13:26 |
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Revised |
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2014-09-02 23:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-10-15 07:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-10-15 07:49 |
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Articles in Press |
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2014-10-15 08:22 |
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Edit the Manuscript by Language Editor |
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2015-02-05 22:45 |
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Typeset the Manuscript |
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2015-03-10 21:33 |
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Publish the Manuscript Online |
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2015-03-19 16:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression of high-mobility group box 1 correlates with lymph node metastasis and poor prognosis in intrahepatic cholangiocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Fei Xu, Fu-Jun Ge, Bo Han, Xiao-Qing Yang, Hong Su, An-Cheng Zhao, Ming-Hong Zhao, Yu-Bao Yang and Jie Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81072110 |
| National Natural Science Foundation of Chin |
81171951 |
| Independent Innovation Foundation of Shandong University |
2010TB012 |
| Scientific Research Foundation for the Returned Overseas Chinese Scholars of Ministry of Education of China |
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| Corresponding Author |
Jie Yang, MD, PhD, Department of Pediatrics, Shandong University Qilu Hospital, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province,
China. yang64662003@163.com |
| Key Words |
Intrahepatic cholangiocarcinoma; High-mobility group box 1; VEGF-C; Lymphatic microvessel density; Epithelial-mesenchymal transition |
| Core Tip |
Cholangiocarcinoma (CCA) is a highly lethal malignancy of the biliary tract with very few treatment options. Novel biomarkers are urgently needed for CCA management and treatment. The novelties of this study are as follows: (1) our study, for the first time, showed that high-mobility group box 1 (HMGB1) is an independent prognostic factor in IHCC and positively correlate with lymphatic microvessel density and vascular endothelial growth factor C (VEGF-C) expressions; and (2) in vitro analysis suggested that HMGB1 enhances the secretion of VEGF-C and promotes Epithelial-mesenchymal transition of RBE cells. In all, our results define an important role of HMGB1 in the progression of cholangiocarcinoma, and HMGB1 may serve as a prognostic marker for IHCC patients.
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| Publish Date |
2015-03-19 16:57 |
| Citation |
Xu YF, Ge FJ, Han B, Yang XQ, Su H, Zhao AC, Zhao MH, Yang YB, Yang J. High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma. World J Gastroenterol 2015; 21(11): 3256-3265 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i11/3256.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i11.3256 |
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