Publication Name	World Journal of Gastroenterology
Manuscript ID	12640
Country	China

Received	2014-07-19 12:14
Peer-Review Started	2014-07-20 09:55
To Make the First Decision	2014-08-15 12:16
Return for Revision	2014-08-20 13:26
Revised	2014-09-02 23:35
Second Decision	2014-10-15 07:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-15 07:49
Articles in Press	2014-10-15 08:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-05 22:45
Typeset the Manuscript	2015-03-10 21:33
Publish the Manuscript Online	2015-03-19 16:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Overexpression of high-mobility group box 1 correlates with lymph node metastasis and poor prognosis in intrahepatic cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Fei Xu, Fu-Jun Ge, Bo Han, Xiao-Qing Yang, Hong Su, An-Cheng Zhao, Ming-Hong Zhao, Yu-Bao Yang and Jie Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81072110 National Natural Science Foundation of Chin 81171951 Independent Innovation Foundation of Shandong University 2010TB012 Scientific Research Foundation for the Returned Overseas Chinese Scholars of Ministry of Education of China
Corresponding Author	Jie Yang, MD, PhD, Department of Pediatrics, Shandong University Qilu Hospital, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. yang64662003@163.com
Key Words	Intrahepatic cholangiocarcinoma; High-mobility group box 1; VEGF-C; Lymphatic microvessel density; Epithelial-mesenchymal transition
Core Tip	Cholangiocarcinoma (CCA) is a highly lethal malignancy of the biliary tract with very few treatment options. Novel biomarkers are urgently needed for CCA management and treatment. The novelties of this study are as follows: (1) our study, for the first time, showed that high-mobility group box 1 (HMGB1) is an independent prognostic factor in IHCC and positively correlate with lymphatic microvessel density and vascular endothelial growth factor C (VEGF-C) expressions; and (2) in vitro analysis suggested that HMGB1 enhances the secretion of VEGF-C and promotes Epithelial-mesenchymal transition of RBE cells. In all, our results define an important role of HMGB1 in the progression of cholangiocarcinoma, and HMGB1 may serve as a prognostic marker for IHCC patients.
Publish Date	2015-03-19 16:57
Citation	Xu YF, Ge FJ, Han B, Yang XQ, Su H, Zhao AC, Zhao MH, Yang YB, Yang J. High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma. World J Gastroenterol 2015; 21(11): 3256-3265
URL	http://www.wjgnet.com/1007-9327/full/v21/i11/3256.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i11.3256

Full Article (PDF)	WJG-21-3256.pdf
Full Article (Word)	WJG-21-3256.doc
Manuscript File	12640-Review.doc
Answering Reviewers	12640-Answering reviewers.pdf
Copyright License Agreement	12640-Copyright assignment.pdf
Peer-review Report	12640-Peer review.pdf
Scientific Misconduct Check	12640-CorssCheck.jpg
Scientific Editor Work List	12640-Scientific editor work list.pdf