Publication Name	World Journal of Stem Cells
Manuscript ID	12660
Country	Germany

Received	2014-07-20 17:32
Peer-Review Started	2014-07-20 18:23
To Make the First Decision	2014-10-14 18:13
Return for Revision	2014-10-20 10:25
Revised
Second Decision	2015-05-15 17:29
Accepted by Journal Editor-in-Chief	2015-05-17 10:21
Accepted by Executive Editor-in-Chief	2015-05-27 14:54
Articles in Press	2015-05-27 15:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-11 13:21
Publish the Manuscript Online	2015-08-01 15:28

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Stem cell autotomy and niche interaction in different systems
Manuscript Source	Invited Manuscript
All Author List	David C Dorn and August Dorn
Funding Agency and Grant Number
Corresponding Author	Dr. David C Dorn, MD, Department of Hematology, Hemostasis, Oncology, and Stem Cell Trans­plantation, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. ddorn_1999@yahoo.com
Key Words	Stem cell-niche interaction; Male germline stem cells; Spermatogenesis; Erythropoiesis; Stem cell autotomy; Thrombopoiesis
Core Tip	A new mode of stem cell-niche interaction has been observed in insects. Male germline stem cells (GSCs) undergo autotomy by serial segregation of vesicles from finger-like projections. These vesicles either accu-mulate at the niche surface or are phagocytized by the niche cells. Autotomized projections are apparently replaced by newly sprouting ones. It is suggested that the unprecedented dynamics of GSC autotomy are involved in a not yet known form of information exchange between GSCs and niche. Apoptotic pathways and autodestruction programs could be involved in GSC autotomy.
Publish Date	2015-08-01 15:28
Citation	Dorn DC, Dorn A. Stem cell autotomy and niche interaction in different systems. World J Stem Cells 2015; 7(6): 922-944
URL	http://www.wjgnet.com/1948-0210/full/v7/i6/922.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i6.922

Full Article (PDF)	WJSC-7-922.pdf
Full Article (Word)	WJSC-7-922.doc
Manuscript File	12660-Review.doc
Answering Reviewers	12660-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12660-Conflict-of-interest statement.pdf
Copyright License Agreement	12660-Copyright assignment.pdf
Peer-review Report	12660-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	12660-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	12660-Scientific misconduct check.pdf
Scientific Editor Work List	12660-Scientific editor work list.pdf