Publication Name	World Journal of Gastroenterology
Manuscript ID	12662
Country	China

Received	2014-07-20 17:21
Peer-Review Started	2014-07-20 19:10
To Make the First Decision	2014-08-15 12:12
Return for Revision	2014-08-19 16:27
Revised	2014-09-10 14:18
Second Decision	2014-10-15 07:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-15 08:17
Articles in Press	2014-10-15 08:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-10-27 03:34
Typeset the Manuscript	2015-03-27 11:21
Publish the Manuscript Online	2015-04-15 11:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Meta-Analysis
Article Title	Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Qi-Bin Song, Qi Wang and Wei-Guo Hu
Funding Agency and Grant Number
Corresponding Author	Qi-Bin Song, Professor, Department of Oncology, Renmin Hospital of Wuhan University, Zhang¬zhidong District, Wuhan 430060, Hubei Province, China. qibinsong@163.com
Key Words	Colorectal neoplasm; Kirsten rat sarcoma viral oncogene homolog; Cetuximab; Panitumumab; Meta-analysis
Core Tip	In this study, we evaluated the correlation between Kirsten rat sarcoma viral oncogene homolog (KRAS) status and the therapeutic effects of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) in patients with metastatic colorectal cancer. We focused on the relationship between KRAS status and the curative effect of anti-EGFR MoAbs in patients with metastatic colorectal cancer, and conducted a systematic meta-analysis of chemotherapy regimens, line of treatment and bevacizumab treatment. This analysis provides the first evidence that patients with wild-type KRAS metastatic colorectal cancer may not benefit from anti-EGFR MoAbs and oxaliplatin-based therapy as first-line treatment. Clinical benefit was confined to therapeutic regimens which included anti-EGFR MoAbs and fluorouracil-based therapy.
Publish Date	2015-04-15 11:01
Citation	Song QB, Wang Q, Hu WG. Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis. World J Gastroenterol 2015; 21(14): 4365-4372
URL	http://www.wjgnet.com/1007-9327/full/v21/i14/4365.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i14.4365

Full Article (PDF)	WJG-21-4365.pdf
Full Article (Word)	WJG-21-4365.doc
Manuscript File	12662-Review.docx
Answering Reviewers	12662-Answering reviewers.pdf
Copyright License Agreement	12662-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12662-Language certificate.PDF
Peer-review Report	12662-Peer review(s).pdf
Scientific Misconduct Check	12662-CrossCheck.jpg
Scientific Editor Work List	12662-Scientific editor work list.pdf