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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 1382 | Download: 1990
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Received |
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2014-07-20 17:21 |
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Peer-Review Started |
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2014-07-20 19:10 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-08-19 16:27 |
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Revised |
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2014-09-10 14:18 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-10-15 07:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-10-15 08:17 |
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Articles in Press |
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2014-10-15 08:28 |
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Edit the Manuscript by Language Editor |
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2014-10-27 03:34 |
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Typeset the Manuscript |
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2015-03-27 11:21 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qi-Bin Song, Qi Wang and Wei-Guo Hu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Qi-Bin Song, Professor, Department of Oncology, Renmin Hospital of Wuhan University, Zhang¬zhidong District, Wuhan 430060, Hubei Province, China. qibinsong@163.com |
| Key Words |
Colorectal neoplasm; Kirsten rat sarcoma viral oncogene homolog; Cetuximab; Panitumumab; Meta-analysis |
| Core Tip |
In this study, we evaluated the correlation between Kirsten rat sarcoma viral oncogene homolog (KRAS) status and the therapeutic effects of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) in patients with metastatic colorectal cancer. We focused on the relationship between KRAS status and the curative effect of anti-EGFR MoAbs in patients with metastatic colorectal cancer, and conducted a systematic meta-analysis of chemotherapy regimens, line of treatment and bevacizumab treatment. This analysis provides the first evidence that patients with wild-type KRAS metastatic colorectal cancer may not benefit from anti-EGFR MoAbs and oxaliplatin-based therapy as first-line treatment. Clinical benefit was confined to therapeutic regimens which included anti-EGFR MoAbs and fluorouracil-based therapy. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Song QB, Wang Q, Hu WG. Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis. World J Gastroenterol 2015; 21(14): 4365-4372 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4365.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4365 |
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