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10/22/2026 2:34:08 AM | Browse: 0 | Download: 0
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Received |
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2026-08-11 03:45 |
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Peer-Review Started |
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2026-08-11 03:46 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-03 06:54 |
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Revised |
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2026-09-06 05:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-08 07:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 08:36 |
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Articles in Press |
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2026-10-08 08:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-15 01:31 |
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Publish the Manuscript Online |
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2026-10-22 02:34 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Characterization of the cellular and transcriptomic landscapes of natural killer cells in hematopoietic microenvironment of myelodysplastic syndrome
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Su-Yun Liu, Xiu-Mei Feng, Zi-Ying Chen, Zhi-Qiang Chen, Yu-Ru Shang, Michael Linnebacher, Yuan-Xin Wang, Shan-Shan Zhang, Min Cai and Lei-Sheng Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province |
ZR2025MS1382 |
| Taishan Scholar Special Funding of Shandong Province Funding |
tsqnz20240858 |
| Science and Technology Development Plan of Jinan Municipal Health Commission |
2025202005 |
| Medical and Health Technology Project of Shandong Province |
202402050122 |
| Clinical Medical Science and Technology Innovation Program of Jinan Science and Technology Bureau |
202430055 |
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| Corresponding Author |
Lei-Sheng Zhang, Director, PhD, Professor, Senior Researcher, Shandong Provincial Key Medical and Health Laboratory of Blood Ecology and Biointelligence, Jinan Key Laboratory of Medical Cell Bioengineering, Science and Technology Innovation Center, The Fourth People’s Hospital of Jinan Affiliated to Shandong Second Medical University, No. 50 Shifan Road, Tianqiao District, Jinan 250031, Shandong Province, China. kczxzls@jn.shandong.cn |
| Key Words |
Myelodysplastic syndrome; Natural killer cells; Bone marrow blood; Cell viability; Transcriptomic signatures |
| Core Tip |
Myelodysplastic syndrome (MDS) are myeloid malignancies of hematopoietic stem cells with limited treatment options. Longitudinal studies have highlighted the tumor microenvironment and dysregulated immune response in MDS, yet the pathogenesis of natural killer cells (NKs) are largely obscure. Therewith, we dissected the biological and transcriptomic signatures of NKs in bone marrow of MDS patients, which would facilitate the further exploration of MDS-NK-meditated pathogenesis and treatment options in future. |
| Publish Date |
2026-10-22 02:34 |
| Citation |
Liu SY, Feng XM, Chen ZY, Chen ZQ, Shang YR, Linnebacher M, Wang YX, Zhang SS, Cai M, Zhang LS. Characterization of the cellular and transcriptomic landscapes of natural killer cells in hematopoietic microenvironment of myelodysplastic syndrome. World J Clin Oncol 2026; 17(10): 126647
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| URL |
https://www.wjgnet.com/2218-4333/full/v17/i10/126647.htm |
| DOI |
https://doi.org/10.5306/wjco.126647 |
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