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Articles Published Processes
10/13/2026 9:29:22 AM | Browse: 1 | Download: 2
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Received |
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2026-08-11 03:46 |
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Peer-Review Started |
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2026-08-11 03:46 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-14 07:35 |
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Revised |
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2026-09-22 09:18 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-09 03:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-09 09:10 |
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Articles in Press |
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2026-10-09 09:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-13 01:28 |
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Publish the Manuscript Online |
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2026-10-13 09:29 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Precision stratification for hepatitis B functional cure: Biomarkers, machine learning and the combination-therapy era
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ahmed Salman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ahmed Salman, FRACP, FRCP, Department of Internal Medicine, Kasr Alainy School of Medicine, 1 Al-Saray Street, Al-Manial, Cairo 11559, Al Qāhirah, Egypt. awea844@gmail.com |
| Key Words |
Hepatitis B virus; Functional cure; Hepatitis B surface antigen; Biomarkers; Machine learning; Hepatocellular carcinoma |
| Core Tip |
A low baseline hepatitis B surface antigen level is associated with response to several investigational regimens, but it should not be treated as a universal treatment-selection threshold. This minireview distinguishes functional cure from other antigen endpoints, separates baseline selection from on-treatment prediction, and appraises model validation, safety, and external validity. No integrated model is available for allocating curative regimens. Hepatocellular carcinoma risk persists after antigen loss; current guideline-based surveillance should continue where indicated, whereas prospective studies should evaluate risk-based refinement. |
| Publish Date |
2026-10-13 09:29 |
| Citation |
Salman A. Precision stratification for hepatitis B functional cure: Biomarkers, machine learning and the combination-therapy era. World J Clin Cases 2026; 14(27): 126695
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| URL |
https://www.wjgnet.com/2307-8960/full/v14/i27/126695.htm |
| DOI |
https://doi.org/10.12998/wjcc.126695 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
