Publication Name	World Journal of Stem Cells
Manuscript ID	1268
Country	France

Received	2012-11-27 14:08
Peer-Review Started	2012-11-28 15:34
To Make the First Decision	2012-12-13 12:33
Return for Revision	2012-12-13 17:30
Revised	2013-05-22 14:23
Second Decision	2013-08-29 07:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-29 09:50
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-17 09:12
Publish the Manuscript Online	2013-10-31 14:50

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Frontier
Article Title	New insights for pelvic radiation disease treatment: Multipotent stromal cell is a promise mainstay treatment for the restoration of abdominopelvic severe chronic damages induced by radiotherapy
Manuscript Source	Invited Manuscript
All Author List	Alain Chapel, Sabine Francois, Luc Douay, Marc Benderitter and Jan Voswinkel
Funding Agency and Grant Number
Corresponding Author	Alain Chapel, PhD, Radiological Protection and Human Health Division, Institute of Radiological Protection and Nuclear Safety, PRP-HOM/SRBE/Laboratory of Radiopathology and Experimental Therapy, BP17, 92262 Fontenay-aux-Roses, France. alain.chapel@irsn.fr
Key Words	Cell therapy; Radiotherapy; Irradiation; Stem cells; Multipotent stromal cells; Mesenchymal stem cells; Clinical trial
Core Tip	Multipotent stromal cells (MSCs) provide a long-term effect in inhibition of chronic inflammation and a fistulisation, arrest of hemorrhagic syndromes for the hemorrhagic cystitis. MSCs are successfully used to treat the late effects of radiotherapies for breast cancer and radiodermatitis. Their efficiency was also demonstrated on pain reduction. Concerning clinical trials to cure abdominal late severe damages of radiotherapy, one compassionate trial has demonstrated the feasibility of cell therapy treatment for patients overdosed.
Publish Date	2013-10-31 14:50
Citation	Chapel A, Francois S, Douay L, Benderitter M, Voswinkel J. New insights for pelvic radiation disease treatment: Multipotent stromal cell is a promise mainstay treatment for the restoration of abdominopelvic severe chronic damages induced by radiotherapy. World J Stem Cells 2013; 5(4): 106-111
URL	http://www.wjgnet.com/1948-0210/full/v5/i4/106.htm
DOI	http://dx.doi.org/10.4252/wjsc.v5.i4.106

Full Article (PDF)	WJSC-5-106.pdf
Manuscript File	1268-Review.doc
Answering Reviewers	1268-Answering reviewers.pdf
Copyright License Agreement	1268-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1268-Language certificate.pdf
Peer-review Report	1268-Peer reviews.pdf
Scientific Editor Work List	1268-Scientific editor work list.doc