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Publication Name World Journal of Clinical Cases
Manuscript ID 126833
Country Egypt
Received
2026-08-14 07:55
Peer-Review Started
2026-08-14 07:55
First Decision by Editorial Office Director
Return for Revision
2026-08-24 09:02
Revised
2026-08-25 10:18
Publication Fee Transferred
Second Decision by Editor
2026-09-16 08:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-16 09:48
Articles in Press
2026-09-16 09:48
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-09-18 01:10
Publish the Manuscript Online
2026-09-18 08:52
ISSN 2307-8960 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Case Report
Article Title Contrasting diagnostic challenges of headache before and after acute disseminated encephalomyelitis in children: Two case reports and review of literature
Manuscript Source Invited Manuscript
All Author List Mohammed Al-Beltagi, Jameel Ahmed Nazeer and Reem M Elbeltagi
ORCID
Author(s) ORCID Number
Mohammed Al-Beltagi http://orcid.org/0000-0002-7761-9536
Jameel Ahmed Nazeer http://orcid.org/0000-0002-0085-9822
Reem M Elbeltagi http://orcid.org/0000-0001-9969-5970
Funding Agency and Grant Number
Funding Agency Grant Number
None
Corresponding Author Mohammed Al-Beltagi, Chairman, Consultant, Head, MD, PhD, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, Bld 1039, Road 2626, Block 226, Tanta 31511, Algharbia, Egypt. mbelrem@hotmail.com
Key Words Acute disseminated encephalomyelitis; Persistent headache; Child; Magnetic resonance imaging; Case report
Core Tip Headache may occur at different stages of pediatric acute disseminated encephalomyelitis (ADEM) and can create distinct diagnostic challenges. In the first case, severe headaches preceded the development of encephalopathy and multifocal neurological abnormalities. In the second, persistent headache continued after neurological recovery and prompted reassessment for ongoing inflammatory disease. Importantly, persistent headache alone does not establish recurrent or multiphasic ADEM. These cases emphasize the importance of interpreting headache based on its temporal relationship to neurological findings and using repeat neuroimaging and cerebrospinal fluid evaluation selectively when clinically indicated.
Publish Date 2026-09-18 08:52
Citation

Al-Beltagi M, Nazeer JA, Elbeltagi RM. Contrasting diagnostic challenges of headache before and after acute disseminated encephalomyelitis in children: Two case reports and review of literature. World J Clin Cases 2026; 14(26): 126833

URL https://www.wjgnet.com/2307-8960/full/v14/i26/126833.htm
DOI https://doi.org/10.12998/wjcc.126833
Full Article (PDF) WJCC-14-126833-with-cover.pdf
CARE Checklist–2016 126833-CARE-Checklist-2016.pdf
Manuscript File 126833_Auto_Edited_011233.docx
Answering Reviewers 126833-answering-reviewers.pdf
Audio Core Tip 126833-audio.mp3
Conflict-of-Interest Disclosure Form 126833-conflict-of-interest-statement.pdf
Copyright License Agreement 126833-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 126833-non-native-speakers.pdf
Peer-review Report 126833-peer-reviews.pdf
Scientific Misconduct Check 126833-scientific-misconduct-check.png
CrossCheck Report 126833-crosscheck-report.pdf