Publication Name	World Journal of Stem Cells
Manuscript ID	12696
Country	Singapore

Received	2014-07-22 19:43
Peer-Review Started	2014-07-23 17:31
To Make the First Decision	2014-08-14 15:00
Return for Revision	2014-08-18 15:57
Revised	2014-08-22 09:18
Second Decision	2014-09-01 15:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-01 15:20
Articles in Press	2014-09-01 15:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-15 12:56
Publish the Manuscript Online	2014-09-25 12:31

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia
Manuscript Source	Invited Manuscript
All Author List	Jian-Biao Zhou and Wee-Joo Chng
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation Singapore Singapore Ministry of Education under its Research Centres of Excellence initiative NMRC Clinician-Scientist IRG Grant CNIG11nov38 NMRC Clinician Scientist Investigator award
Corresponding Author	Jian-Biao Zhou, MD, PhD, Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 28 Medical Drive, Singapore 117456, Singapore. csizjb@nus.edu.sg
Key Words	Acute myeloid leukemia; Leukemia stem cell; Immuontherapy; Cancer stem cell; Cell therapy
Core Tip	Acute Myeloid Leukemia (AML) remains an incurable disease in most of cases. Leukemia stem cells (LSC) are a subpopulation of leukemic cells responsible for the continued proliferation and propagation of bulk leukemic cells. Growing evidence support the notion that LSCs are the root source of disease relapse and treatment resistance. Here we review the literature on historical overview of the discovery of LSC, identification and separation of LSC and strategies of targeting LSC as a potential cure for AML.
Publish Date	2014-09-25 12:31
Citation	Zhou J, Chng WJ. Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia. World J Stem Cells 2014; 6(4): 473-484
URL	http://www.wjgnet.com/1948-0210/full/v6/i4/473.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i4.473

Full Article (PDF)	WJSC-6-473.pdf
Full Article (Word)	WJSC-6-473.doc
Manuscript File	12696-Review.doc
Answering Reviewers	12696-Answering reviewers.pdf
Copyright License Agreement	12696-Copyright assignment.pdf
Peer-review Report	12696-Peer review(s).pdf
Scientific Misconduct Check	12696-Crosscheck.jpg
Scientific Editor Work List	12696-Scientific editor work list.pdf