Publication Name	World Journal of Hepatology
Manuscript ID	12723
Country	South Korea

Received	2014-07-23 20:36
Peer-Review Started	2014-07-25 20:34
To Make the First Decision	2014-08-14 14:57
Return for Revision	2014-08-15 10:00
Revised	2014-08-27 07:50
Second Decision	2014-10-16 15:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-16 15:41
Articles in Press	2014-10-16 15:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 09:16
Publish the Manuscript Online	2014-11-20 19:46

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Topic Highlights
Article Title	Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Hye-jin Yoon and Bong Soo Cha
Funding Agency and Grant Number
Corresponding Author	Bong Soo Cha, MD, PhD, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemoon-gu, Seoul 120-752, South Korea. bscha@yuhs.ac
Key Words	Non-alcoholic fatty liver disease; Insulin resistance; Drugs; Pathogenesis
Core Tip	In this review, we summarize the pathogenesis underlying the progression of hepatic steatosis to steatohepatitis and cirrhosis. We also discuss established drugs that are already being used to treat non-alcoholic fatty liver disease, in addition to newly discovered agents, with respect to their mechanisms of drug action, focusing mainly on hepatic insulin resistance. As well, we review clinical data that demonstrate the efficacy of these drugs, together with improvements in biochemical or histological parameters. Furthermore, we introduced future treatment option for non-alcoholic fatty liver disease.
Publish Date	2014-11-20 19:46
Citation	Yoon HJ, Cha BS. Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease. World J Hepatol 2014; 6(11): 800-811
URL	http://www.wjgnet.com/1948-5182/full/v6/i11/800.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i11.800

Full Article (PDF)	WJH-6-800.pdf
Full Article (Word)	WJH-6-800.doc
Manuscript File	12723-Review.doc
Answering Reviewers	12723-Answering reviewers.pdf
Copyright License Agreement	12723-Copyright assignment.pdf
Peer-review Report	12723-Peer review(s).pdf
Scientific Misconduct Check	12723-CrossCheck.jpg
Scientific Editor Work List	12723-Scientific editor work list.pdf