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Articles Published Processes
9/28/2014 2:57:00 PM | Browse: 1214 | Download: 1241
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Received |
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2014-07-23 20:19 |
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Peer-Review Started |
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2014-07-24 17:24 |
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To Make the First Decision |
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2014-08-28 14:41 |
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Return for Revision |
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2014-08-29 14:15 |
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Revised |
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2014-09-03 17:22 |
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Second Decision |
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2014-09-17 14:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-17 14:36 |
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Articles in Press |
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2014-09-17 14:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-09-22 17:37 |
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Publish the Manuscript Online |
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2014-09-28 14:56 |
Category |
Cell Biology |
Manuscript Type |
Minireviews |
Article Title |
Cell signalling pathways underlying induced pluripotent stem cell reprogramming
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Manuscript Source |
Invited Manuscript |
All Author List |
Kate Hawkins, Shona Joy and Tristan McKay |
Funding Agency and Grant Number |
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Corresponding Author |
Dr. Kate Hawkins, Molecular Cell Sciences, St George’s University of London, Cranmer Terrace, London, SW17 0RE, United Kingdom. k.hawkins@sgul.ac.uk |
Key Words |
Pluripotency; Reprogramming; Induced pluripotent stem; Cell signalling; Embryonic stem |
Core Tip |
Induced pluripotent stem (iPS) cells present great promise, both to research and to medicine. However, we know very little regarding the mechanisms that occur throughout the iPS cell reprogramming process and thus the process remains inefficient. In this review, we discuss the 3 stages of reprogramming, initiation, maturation and stabilisation, and clarify the signalling pathways underlying each phase. We draw together the current knowledge to propose a model for the interactions between the key pathways in iPS cell reprogramming with the aim of illuminating this complex yet fascinating process. |
Publish Date |
2014-09-28 14:56 |
Citation |
Hawkins K, Joy S, McKay T. Cell signalling pathways underlying induced pluripotent stem cell reprogramming. World J Stem Cells 2014; 6(5): 620-628 |
URL |
http://www.wjgnet.com/1948-0210/full/v6/i5/620.htm |
DOI |
http://dx.doi.org/10.4252/wjsc.v6.i5.620 |
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