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Articles Published Processes
11/4/2026 3:47:11 AM | Browse: 1 | Download: 1
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Received |
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2026-08-27 03:11 |
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Peer-Review Started |
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2026-08-27 03:11 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-16 08:52 |
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Revised |
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2026-09-21 06:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-30 03:06 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-30 03:28 |
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Articles in Press |
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2026-10-30 03:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-11-02 00:31 |
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Publish the Manuscript Online |
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2026-11-04 03:47 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Review |
| Article Title |
Molecularly guided therapy in gastrointestinal malignancies: From established targets to resistance and emerging precision strategies
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Himanshu Agrawal, Sahil Goel and Nikhil Gupta |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Himanshu Agrawal, Associate Professor, Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Dilshad Garden, Delhi 110095, India. himagr1987@gmail.com |
| Key Words |
Gastrointestinal neoplasms; Precision medicine; Tumor biomarkers; Neoplasm drug resistance; Antineoplastic agents |
| Core Tip |
Molecularly targeted therapy has transformed the management of selected gastrointestinal malignancies by linking specific genomic or protein alterations to individualized treatment. This narrative review summarizes established and emerging molecular targets across colorectal, gastric and gastroesophageal junction, biliary, pancreatic, and gastrointestinal stromal tumors, while contextualizing therapies according to clinical evidence, biomarker requirements, and resistance mechanisms. Emerging approaches—including circulating tumor DNA, antibody–drug conjugates, bispecific antibodies, KRAS-directed therapies, and targeted–immunotherapy combinations—may help address treatment resistance, although their clinical roles vary in maturity and require continued prospective evaluation. |
| Publish Date |
2026-11-04 03:47 |
| Citation |
Agrawal H, Goel S, Gupta N. Molecularly guided therapy in gastrointestinal malignancies: From established targets to resistance and emerging precision strategies. World J Transl Med 2026; 12(4): 127329
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| URL |
https://www.wjgnet.com/2220-6132/full/v12/i4/127329.htm |
| DOI |
https://doi.org/10.5528/wjtm.127329 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
