Publication Name	World Journal of Diabetes
Manuscript ID	12733
Country	Germany

Received	2014-07-24 18:11
Peer-Review Started	2014-07-25 21:04
To Make the First Decision	2014-09-16 11:00
Return for Revision	2014-09-16 16:36
Revised	2014-09-18 14:36
Second Decision	2015-01-14 08:22
Accepted by Journal Editor-in-Chief	2015-01-14 12:11
Accepted by Executive Editor-in-Chief	2015-01-20 16:45
Articles in Press	2015-01-20 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-07 08:32
Publish the Manuscript Online	2015-04-20 09:13

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Nociception at the diabetic foot, an uncharted territory
Manuscript Source	Invited Manuscript
All Author List	Ernst A Chantelau
Funding Agency and Grant Number
Corresponding Author	Ernst A Chantelau, Professor, Diabetic Foot Clinic, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40001 Düsseldorf, Germany. chantelau@gmx.de
Key Words	Foot ulcer; Neuroarthropathy; Insensitivity to pain; Pain perception; Diabetes mellitus; Amputation; Diabetic neuropathy
Core Tip	The diabetic foot is characterised by painless ulcers and/or arthropathy. Although painless diabetic neuropathy is known as the underlying condition, little is known quantitatively about the pain evoked by noxious stimuli (nociception) at the diabetic foot. Preliminary evidence shows that pinprick pain perception threshold at plantar digital skinfolds is supranormal, beyond the upper limits of measurement. It is suggested that measuring nociception at the foot in diabetes could specify the individual risk of painless ulcers and/or arthropathy and, thereby, provide the basis of an individualised graded injury prevention strategy.
Publish Date	2015-04-20 09:13
Citation	Chantelau EA. Nociception at the diabetic foot, an uncharted territory. World J Diabetes 2015; 6(3): 391-402
URL	http://www.wjgnet.com/1948-9358/full/v6/i3/391.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i3.391

Full Article (PDF)	WJD-6-391.pdf
Full Article (Word)	WJD-6-391.doc
Manuscript File	12733-Review.doc
Answering Reviewers	12733-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12733-Conflict-of-interest statement.jpg
Copyright License Agreement	12733-Copyright assignment.pdf
Peer-review Report	12733-Peer review(s).pdf
Scientific Misconduct Check	12733-CrossCheck.jpg
Scientific Editor Work List	12733-Scientific editor work list.pdf