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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 1319 | Download: 1718
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Received |
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2014-07-24 09:20 |
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Peer-Review Started |
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2014-07-24 18:21 |
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To Make the First Decision |
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2014-08-18 11:18 |
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Return for Revision |
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2014-08-18 18:08 |
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Revised |
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2014-08-19 03:36 |
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Second Decision |
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2014-10-21 17:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-21 17:49 |
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Articles in Press |
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2014-10-21 18:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-11-03 07:09 |
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Typeset the Manuscript |
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2015-03-23 11:40 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai Qu, Su-Shun Liu, Zhi-Xin Wang, Zi-Chao Huang, Si-Nan Liu, Hu-Lin Chang, Xin-Sen Xu, Ting Lin, Ya-Feng Dong and Chang Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81201549 |
| National Natural Science Foundation of China |
81272644 |
| Project of Innovative Research Team for Key Science and Technology in Xi’an Jiaotong University |
2003KCJ-23 |
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| Corresponding Author |
Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com |
| Key Words |
Glutathione S-transferase; Polymorphism; Hepatocellular carcinoma; Clinical outcome; Surgery |
| Core Tip |
To determine the prognostic value of single nucleotide polymorphisms (SNPs) in GST genes in hepatocellular carcinoma (HCC) after liver resection, we analyzed the association between 12 tagging SNPs in GST genes and outcome of 214 HCC patients who underwent liver resection. Our data showed two SNPs (GSTO2: rs7085725 and GSTP1: rs4147581) to be significantly associated with overall survival in HCC patients. These two SNPs used in combination were more powerful prognostic markers for HCC patients. Our study provides the first evidence that GSTO2 and GSTP1 gene polymorphisms may serve as independent prognostic markers for HCC patients. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Qu K, Liu SS, Wang ZX, Huang ZC, Liu SN, Chang HL, Xu XS, Lin T, Dong YF, Liu C. Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. World J Gastroenterol 2015; 21(14): 4310-4322 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4310.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4310 |
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